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EC number: 267-008-6 | CAS number: 67762-27-0 This substance is identified by SDA Substance Name: C16-C18 alkyl alcohol and SDA Reporting Number: 19-060-00.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to other above-ground organisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to other above-ground organisms
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Justification for type of information:
- Alcohols, C16-18 is a member and is from Long Chain Alcohols (C6-22 primary aliphatic alcohols) category.
The Long Chain Alcohols (C6-22 primary aliphatic alcohols) category is considered suitable as a source of data for Alcohols, C16-18.
Considered valid for read-across for purposes of classification.
No further vertebrate testing can be justified.
Long Chain Alcohols (C6-22 primary aliphatic alcohols) category covers a family of 30 primary aliphatic alcohols within a carbon chain length range of C6-C22. Commercial products generally include several aliphatic alcohol components, with a range of carbon chain lengths present. The family consists of alcohols with varying compositions and structures. Composition depends on the route to manufacture and the related feedstocks. Most of the alcohols have linear carbon chains but certain manufacturing processes create branched structures. Data are also available for eleven other similar substances, which support the category. Non-sponsored alcohols may not be HPV or may not be produced by members of the consortium, but have structures similar to sponsored linear alcohols.
Key points are that the members share:
• The same structural features
• Similar metabolic pathways
• Common mode of ecotoxicological action
• Common levels and mode of human health related effects. - Reason / purpose for cross-reference:
- read-across: supporting information
- Qualifier:
- according to guideline
- Guideline:
- EPA OPP 71-3 (Wild Mammal Acute Toxicity Test)
- GLP compliance:
- not specified
- Analytical monitoring:
- no
- Vehicle:
- yes
- Test organisms (species):
- rat
- Details on test organisms:
- TEST ORGANISMS:
Rattus norvegicus (Norway Rat). The sexually mature organism(s) (age: 68-85 d and organism characteristics of: 365.1 G,PREGNANT, OUTBRED STRAIN/) - Study type:
- laboratory study
- Limit test:
- no
- Total exposure duration:
- 20 d
- Test temperature:
- 10-20 0C
Temperature was continuously recorded - Photoperiod and lighting:
- They were held at a photoperiod of 14:10 light:dark.
- Nominal and measured concentrations:
- DOSES/130/650/975/1300 mg/kg/d
- Reference substance (positive control):
- not specified
- Duration:
- 10 d
- Dose descriptor:
- other: NOEL
- Effect conc.:
- 130 mg/kg bw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: NR-ZERO was reported (NOEL) Zero Mortality: 0% mortality or 100% survival of organisms. (No statistically derived endpoint reported)
- Duration:
- 10 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 2 600 mg/kg diet
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks:
- TheNOELs can be converted to NOECs with the following two formulae: NOECrat=NOELrat.CONVrat Conversion factors from NOEL to NOEC for mammalian species Rattus norvegicus (> 6 weeks) is 20 (bw/dfi)
- Basis for effect:
- mortality
- Remarks on result:
- other: NOECrat=130 x 20=2600 mg/kg/diet Conversion factors from NOEL to NOEC for mammalian species Rattus norvegus >6 weeks is 20 (bw/dfi) bw = body weight (g); dfi: daily food intake (g/day)
- Duration:
- 20 d
- Dose descriptor:
- other: NOEL
- Effect conc.:
- 1 300 mg/kg bw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- behaviour
- Remarks:
- Measurement: Abnormal,Weight;
- Duration:
- 20 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 26 000 mg/kg diet
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks:
- TheNOELs can be converted to NOECs with the following two formulae: NOECrat=NOELrat.CONVrat Conversion factors from NOEL to NOEC for mammalian species Rattus norvegicus (> 6 weeks) is 20 (bw/dfi)
- Basis for effect:
- behaviour
- Remarks:
- Measurement: Abnormal,Weight;
- Remarks on result:
- other: NOECrat=1300 x 20=26000 mg/kg/diet Conversion factors from NOEL to NOEC for mammalian species Rattus norvegus >6 weeks is 20 (bw/dfi) bw = body weight (g); dfi: daily food intake (g/day)
- Details on results:
The NOEL for the Rattus norvegicus was 130 mg/kg bw for mortality
The NOEL for the Rattus norvegicus was 1300 mg/kg bw for Abnormal and Weight effects
For the assessment of secondary poisoning, the results always have to be expressed as the concentration in food in order to be able to compare it to the PEC.
TheNOELs can be converted to NOECs with the following two formulae:
NOECrat=NOELrat.CONVrat
Conversion factors from NOEL to NOEC for mammalian species Rattus norvegicus (> 6 weeks) is 20 (bw/dfi)
bw = body weight (g); dfi: daily food intake (g/day)
NOECrat=130 x 20=2600 mg/kg/diet- Validity criteria fulfilled:
- yes
- Conclusions:
- The NOEL for the Rattus norvegicus was 130 mg/kg bw for mortality
The NOEL for the Rattus norvegicus was 1300 mg/kg bw for Abnormal and Weight effects
For the assessment of secondary poisoning, the results always have to be expressed as the concentration in food in order to be able to compare it to the PEC.
TheNOELs can be converted to NOECs with the following two formulae:
NOECrat=NOELrat.CONVrat
Conversion factors from NOEL to NOEC for mammalian species Rattus norvegicus (> 6 weeks) is 20 (bw/dfi)
bw = body weight (g); dfi: daily food intake (g/day)
NOECrat=130 x 20=2600 mg/kg/diet - Executive summary:
The NOEL for the Rattus norvegicus was 130 mg/kg bw for mortality The NOEL for the Rattus norvegicus was 1300 mg/kg bw for Abnormal and Weight effects For the assessment of secondary poisoning, the results always have to be expressed as the concentration in food in order to be able to compare it to the PEC. TheNOELs can be converted to NOECs with the following two formulae: NOECrat=NOELrat.CONVrat Conversion factors from NOEL to NOEC for mammalian species Rattus norvegicus (> 6 weeks) is 20 (bw/dfi) bw = body weight (g); dfi: daily food intake (g/day) NOECrat=130 x 20=2600 mg/kg/diet
- Endpoint:
- toxicity to other above-ground organisms
- Data waiving:
- other justification
- Justification for data waiving:
- other:
Referenceopen allclose all
A study of NC-NC Not Coded duration using no substrate
media was conducted in a Lab site location with Not Coded
obtained Rattus norvegicus (Norway Rat). The sexually
mature organism(s) (age: 68-85 d and organism
characteristics of: 365.1 G,PREGNANT, OUTBRED STRAIN/) were
exposed for a duration of 10 day(s) to a(n) 10 Daily
for X days application of 1-Octanol (CAS # 111875) in NR
carrier or a(n) NR positive control through a(n) gavage
exposure route. The reported chemical concentrations are the result of unmeasured
analysis of chemical solutions and are based on the NR ion.
(Reference 84162, Hellwig, J., and R. Jackh, 1997, Test Number 406282).
Description of key information
The NOEL for the Rattus norvegicus was 130 mg/kg bw for mortality
The NOEL for the Rattus norvegicus was 1300 mg/kg bw for Abnormal and Weight effects
For the assessment of secondary poisoning, the results always have to be expressed as the concentration in food in order to be able to compare it to the PEC.
TheNOELs can be converted to NOECs with the following two formulae:
NOECrat=NOELrat.CONVrat
Conversion factors from NOEL to NOEC for mammalian species Rattus norvegicus (> 6 weeks) is 20 (bw/dfi)
bw = body weight (g); dfi: daily food intake (g/day)
NOECrat=130 x 20=2600 mg/kg/diet
Key value for chemical safety assessment
- Short-term EC50 or LC50 for mammals:
- 13 000 mg/kg food
- Long-term EC10, LC10 or NOEC for mammals:
- 2 600 mg/kg food
Additional information
The NOEL for the Rattus norvegicus was 130 mg/kg bw for mortality
The NOEL for the Rattus norvegicus was 1300 mg/kg bw for Abnormal and Weight effects
For the assessment of secondary poisoning, the results always have to be expressed as the concentration in food in order to be able to compare it to the PEC.
TheNOELs can be converted to NOECs with the following two formulae:
NOECrat=NOELrat.CONVrat
Conversion factors from NOEL to NOEC for mammalian species Rattus norvegicus (> 6 weeks) is 20 (bw/dfi) bw = body weight (g); dfi: daily food intake (g/day)
NOECrat=130 x 20=2600 mg/kg/diet
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