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EC number: 202-200-5 | CAS number: 92-88-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
- Remarks:
- Conducted to OECD test guideline. GLP study with chemical analysis by HPLC
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- GLP compliance:
- yes
- Specific details on test material used for the study:
- Biphenyl-4,4’-diol / CAS 92-88-6
- Analytical monitoring:
- yes
- Details on sampling:
- Samples of prepared test medium were taken at 0 hours (fresh) and 24 hours (old)
- Vehicle:
- yes
- Details on test solutions:
- Test solution prepared by dissolution of weighed quantities of test substance into solvent dimethyl formamide (DMF) followed by dilution in Elendt M4 medum at a volume of 100 uL/L
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- Test organisms were supplied from an internal laboratory culture that was fed chlorella vulgaris (0.2 mg Carbon)
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Post exposure observation period:
- NA
- Hardness:
- 244 to 248 (0-24 hours)
- Test temperature:
- 19.9 to 20.1°C
- pH:
- 8.3 to 8.5
- Dissolved oxygen:
- 8.5 to 8.8 mg/L
- Salinity:
- NA
- Nominal and measured concentrations:
- Nominal concentrations of 0.5, 0.85, 1.4, 2.4, 4.1 and 7.0 mg/L
Measured concentrations: 0.513, 0.86, 1.44, 2.48, 4.17 and 7.25 mg/L - Details on test conditions:
- A 48 hour acute toxicity test was conducted in accordance with OECD 202 Acute toxicity to Daphnia magna, under semi-static conditions. Based on the results of a range finding test a definitive test was conducted at nominal concentration of 0.5, 0.85, 1.4, 2.4, 4.1 and 7.0 mg/L. Four
replicate test vessels were prepared per test concentration containing 100 mL of test medium and 5 Daphnia per vessel (20 per concentration in
total).
The test was conducted with a 16 hour light and 8 hour dark lighting regime at (ca. 800 Lux).
Test solutions were prepared by direct weighing and dilution in a solvent vehicle (DMF) prior to dilution (100 µL/L) in Elendt M4 medium.
Concentrations were confirmed at 0 and 24 hours, 103 to 106% and 99 to 102% respectively (LOD 0.0002 mg/L). - Reference substance (positive control):
- not specified
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 7.25 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- 0.86 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 24 h
- Dose descriptor:
- LC100
- Effect conc.:
- > 7.25 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 1.76 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: between 1.47 and 2.11
- Key result
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.513 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC100
- Effect conc.:
- 7.25 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- There was no control or solvent control immobility during the conduct of the test
- Results with reference substance (positive control):
- NA
- Reported statistics and error estimates:
- Probit
- Validity criteria fulfilled:
- yes
- Conclusions:
- The 48 hour EC50 was calculated to be 1.76 mg/L
The 48 hour NOEC was considered to be 0.860 mg/L - Executive summary:
A GLP 48 hour semi-static acute toxicity test was conducted with 4,4 -biphenol in accordance with OECD 202 Acute toxicity to Daphnia magna, under semi-static conditions using Elendt M4. Based on the results of a range finding test a definitive test was conducted at nominal concentration of 0.5, 0.85, 1.4, 2.4, 4.1 and 7.0 mg/L.
Geometric mean measured concentrations were: 0.513, 0.86, 1.44, 2.48, 4.17 and 7.25 mg/L.
The 48 hour EC50was calculated to be 1.76 mg/L (based on geometric mean measured concentrations)
The 48 hour NOEC was considered to be 0.860 mg/L (based on geometric mean measured concentrations)
Reference
Immobility results
Nominal concentration (mg/L) |
Geometric mean measured concentration |
% Immobility |
|
24 hours |
48 hours |
||
Control |
- |
0 |
0 |
Solvent control |
- |
0 |
0 |
0.5 |
0.513 |
0 |
0 |
0.85 |
0.860 |
0 |
5 |
1.4 |
1.44 |
10 |
50 |
2.4 |
2.48 |
10 |
65 |
4.1 |
4.17 |
20 |
95 |
7.0 |
7.25 |
25 |
100 |
Analytical results
Nominal concentration (mg/L) | Measured concentrations (mg/L) | Geometric mean measured concentrations (mg/L) | |
0 hours | 24 hours | ||
Control | <LOD | <LOD | <LOD |
Solvent control | <LOD | <LOD | <LOD |
0.5 | 0.52 | 0.506 | 0.513 |
0.85 | 0.879 | 0.842 | 0.86 |
1.4 | 1.47 | 1.42 | 1.44 |
2.4 | 2.54 | 2.43 | 2.48 |
4.1 | 4.21 | 4.14 | 4.17 |
7 | 7.35 | 7.15 | 7.25 |
Description of key information
Nominal concentrations: 3.0, 5.3, 9.5, 17 and 30 mg/L (spacing factor 1.8)
Measured concentrations: 101-105% (0 hours), 99-106% (24 hours) analysis by HPLC.
96 hour EC50 = 1.76 mg/L (CI 95% 1.47 to 2.11 mg/L)
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 1.76 mg/L
Additional information
A GLP 48 hour semi-static acute toxicity test was conducted with biphenyl-4,4'-diol in accordance with OECD 202 Acute toxicity to Daphnia magna, under semi-static conditions using Elendt M4. Based on the results of a range finding test a definitive test was conducted at nominal concentration of 0.5, 0.85, 1.4, 2.4, 4.1 and 7.0 mg/L.
Geometric mean measured concentrations were: 0.513, 0.86, 1.44, 2.48, 4.17 and 7.25 mg/L.
The 48 hour EC50was calculated to be 1.76 mg/L (based on geometric mean measured concentrations)
The 48 hour NOEC was considered to be 0.860 mg/L (based on geometric mean measured concentrations)
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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