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Diss Factsheets
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EC number: 931-254-9 | CAS number: 64742-49-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 1970
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: This study is classified as reliable with restrictions because it is an acceptable well-documented publication which meets basic scientific principles.
- Justification for type of information:
- A discussion and report on the read across strategy is given as an attachment in IUCLID Section 13.
Cross-reference
- Reason / purpose for cross-reference:
- read-across: supporting information
Reference
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 1970
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: This study is classified as reliable with restrictions because it is an acceptable well-documented publication which meets basic scientific principles.
- Justification for type of information:
- A discussion and report on the read across strategy is given as an attachment in IUCLID Section 13.
- Reason / purpose for cross-reference:
- read-across source
- Key result
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- 73 860 ppm
- Exp. duration:
- 4 h
- Remarks on result:
- other: 259354 mg/m3
- Mortality:
- All deaths occurred during exposure, except one rat in the 81800 ppm group that died on day 6.
- Clinical signs:
- other: Surviving rats were uncoordinated, prostrate or comatose during exposure but recovered within a few hours of removal from the chamber. The rat that died on day 6 had convulsions during and after exposure.
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- The 4-hr LC50 for rats exposed by inhalation was 73,680 ppm.
- Executive summary:
This data is being read across from the source study that tested commercial hexane based on analogue read across.
This study examined that acute inhalation toxicity of hexane to male rats. Groups of 10 male rats exposed to various large concentrations of hexane vapor for 4 hrs. Animals were then observed for clinical signs and mortality for at least the next 6 days. Several animals died during the exposure period. Surviving animals experienced severe toxicological effects during the exposure. One animal experienced convulsions during and after exposure, and died on day 6 post-exposure. The LC50 was determined to be 73,680 ppm (259354 mg/m3). Due to the high concentration of the LC50, the test substance would not be classified as toxic by inhalation according to OECD GHS guidelines.
Data source
Reference
- Reference Type:
- publication
- Title:
- The Toxicological Properties of Hydrocarbon Solvents
- Author:
- Hine, CH, and Zuidema, HH
- Year:
- 1 970
- Bibliographic source:
- Industrial Medicine, Vol. 39, No. 5, May 1970.
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- GLP compliance:
- no
- Test type:
- acute toxic class method
Test material
- Reference substance name:
- C-6 normal and iso paraffins (hexanes) and naphthenes (methyl-cyclohexane, dimethylcyclohexane), 25-35% n-hexane
- IUPAC Name:
- C-6 normal and iso paraffins (hexanes) and naphthenes (methyl-cyclohexane, dimethylcyclohexane), 25-35% n-hexane
- Details on test material:
- - Name of test material (as cited in study report): S-1
- Composition of test material, percentage of components: C-6 normal and iso paraffins (hexanes) and naphthenes (methyl-cyclohexane, dimethylcyclohexane), 25-35% n-hexane
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Long-Evans
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 150-300 g
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- not specified
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure chamber volume: 250 l
- Method of conditioning air: Sample was heated in a water bath at 77 degree F. Air was bubbled through the sample and entered the exposure chamber. For concentrations less than saturation, air flow was divided with part passing over the sample and part passing directly into the exposure chamber.
TEST ATMOSPHERE
- Brief description of analytical method used: GLC - Duration of exposure:
- 4 h
- Concentrations:
- 73,680 ppm (30-40% of saturation at 25 degree C)
81,800 ppm - No. of animals per sex per dose:
- 10 males
- Details on study design:
- - Duration of observation period following administration: at least 6 days
Results and discussion
Effect levels
- Key result
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- 73 860 ppm
- Exp. duration:
- 4 h
- Remarks on result:
- other: 259354 mg/m3
- Mortality:
- All deaths occurred during exposure, except one rat in the 81800 ppm group that died on day 6.
- Clinical signs:
- other: Surviving rats were uncoordinated, prostrate or comatose during exposure but recovered within a few hours of removal from the chamber. The rat that died on day 6 had convulsions during and after exposure.
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- The 4-hr LC50 for rats exposed by inhalation was 73,680 ppm.
- Executive summary:
This study examined that acute inhalation toxicity of hexane to male rats. Groups of 10 male rats exposed to various large concentrations of hexane vapor for 4 hrs. Animals were then observed for clinical signs and mortality for at least the next 6 days. Several animals died during the exposure period. Surviving animals experienced severe toxicological effects during the exposure. One animal experienced convulsions during and after exposure, and died on day 6 post-exposure. The LC50 was determined to be 73,680 ppm (259354 mg/m3). Due to the high concentration of the LC50, the test substance would not be classified as toxic by inhalation according to OECD GHS guidelines.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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