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EC number: 404-450-2 | CAS number: 118685-34-0 COBRATEC 435
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1989
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.3 (Acute Toxicity (Dermal))
- Version / remarks:
- Annex V of ECC Directive 79/831/EEC; part B methods for determination of toxicity. Method B3 Acute Dermal Toxicity
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- Sodium 5-N-butylbenzotriazole
- EC Number:
- 404-450-2
- EC Name:
- Sodium 5-N-butylbenzotriazole
- Cas Number:
- 118685-34-0
- Molecular formula:
- CCCCc1ccc2c(c1)nnn2[Na]
- IUPAC Name:
- sodium 5-butyl-1H-1,2,3-benzotriazol-1-ide
- Test material form:
- solid - liquid: aqueous solution
- Details on test material:
- Butyl benzotriazole (free acid) was prepared at a concentration of 62.5% w/v in distilled water.
Constituent 1
- Specific details on test material used for the study:
TREATMENT OF TEST MATERIAL PRIOR TO TESTING
- Final dilution of a dissolved solid, stock liquid or gel: Butyl benzotriazole (free acid), a brown powder, was prepared at a concentration of 62.5% W/V in distilled water.
FORM: dilution of powder
Test animals
- Species:
- rat
- Strain:
- Crj: CD(SD)
- Remarks:
- Crl: CD (SD) BR VAF plus
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River France
- Age at study initiation: 7 to 10 weeks
- Weight at study initiation: 202 to 250 g
- Fasting period before study: no
- Housing: individually in metal cages with wire mesh floors.
- Diet (e.g. ad libitum): A standard laboratory rodent diet (Biosure LAD 1) ad libitum.
- Water (e.g. ad libitum): Domestic quality potable water ad libitum.
- Acclimation period: 21 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): THe mean daily minimum and maximumm teperatures of the animal room were 21°C and 24°C respectively.
- Humidity (%): 51%RH
- Air changes (per hr): 15 air changes/hour
- Photoperiod (hrs dark / hrs light): 12hrs dark / 12 hrs artificial light
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure:
- % coverage: 10%
- Type of wrap if used: Gauze which was held in place with an impermeable dresssing encircled firmly around the trunk.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): treated area of skin was decontaminated by washing in warm (30-40°C) water abd blotting dry with absorbent paper.
- Time after start of exposure: 24h
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 3.2ml/kg
- Concentration (if solution): 62.5%
- Constant volume or concentration used: yes - Duration of exposure:
- 24h
- Doses:
- 2.0 g/kg
- No. of animals per sex per dose:
- 5 males
5 females - Control animals:
- not required
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Animals were observed soon ager dosing and at frequent intervals for the remainder of day 1 ( a period of 5 hours). On subsequent days the animals were observed once in the morning and again at the end of the experimental day.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs (erythema, oedema), body weight (day 1, 8 and 15), Macroscopic post mortem examination
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- other:
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- no indication of skin irritation up to the relevant limit dose level
- Mortality:
- No deaths
- Clinical signs:
- other: There were no signs of systemic reaction to treatment
- Gross pathology:
- Sites of application showed no irritation reactions or other dermal changes
Applicant's summary and conclusion
- Executive summary:
The acute dermal toxicity to rats of Butyl benzotriazole was tested based on what recommeded under Annex V of EEC Directive 79/831/EEC, Part B Methods for determination of toxicity. Method B3 Acute Dermal Toxicity, and the OECD guideline for Testing of Chemicals No. 402 "Acute Dermal Toxicity". A group of 10 rats was treated at 2.0 g/kg bodyweight.
The acute lethal dose to rats of Butyl benzotriazile (free acid) was found to be greater than 2.0 g/kg bodyweight.
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