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EC number: 231-913-4 | CAS number: 7778-77-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Testing was conducted between 30 September 2009 and 24 October 2009.
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Date of inspection: 15-09-2009 Date of Signature: 26-11-2009
- Type of method:
- flask method
- Remarks:
- The determination was carried out using the flask method, Method A6 Water Solubility of Commission Regulation (EC) No 440/2008 of 30 May 2008.
- Water solubility:
- 208 g/L
- Temp.:
- 20 °C
- pH:
- >= 4.2 - <= 4.5
- Details on results:
- Please see section Remarks on results including tables and figures.
- Conclusions:
- Interpretation of results: very soluble (> 10000 mg/L)
The water solubility of the test material has been determined to be 208 g/l of solution at 20.0 ± 0.5°C.
The effect of temperature over the range 10 to 30°C has been considered not to have had a significant influence on the observed solubility of the test material (range 173 to 239 g/l).
An assessment of the solubility of the test material over the environmentally relevant pH range of 4 to 9 gave solubility results and final solution pH’s similar to those obtained using unbuffered water. Thus, it can be anticipated that the water solubility of the test material over the pH range 4 to 9 would be constant, essentially due to the low buffering activities seen in the environment.
This study is conducted according to an appropriate guideline and under the conditions of GLP and therefore the study is considered to be acceptable and to adequately satisfy both the guideline requirement and the regulatory requirement as a key study for this endpoint. - Executive summary:
Method
The determination was carried out using the flask method, Method A6 Water Solubility ofCommissionRegulation (EC) No 440/2008 of 30 May 2008.
The water solubility of the test material has been determined to be 208 g/l of solution at 20.0±0.5°C.
The effect of temperature over the range 10 to 30°C has been considered not to have had a significant influence on the observed solubility of the test material (range 173 to 239 g/l).
An assessment of the solubility of the test material over the environmentally relevant pH range of 4 to 9 gave solubility results and final solution pH’s similar to those obtained using unbuffered water. Thus, it can be anticipated that the water solubility of the test material over the pH range 4 to 9 would be constant, essentially due to the low buffering activities seen in the environment.
Reference
Results
Preliminary test
The mean peak areas relating to the standard and sample solutions are shown in the following table:
Table 6.6
Solution |
Mean peak area* |
Standard 30.0 mg/l |
3.092 |
Standard 30.1 mg/l |
3.239 |
Sample 1C** |
1.598 |
Sample 2C** |
1.765 |
*corrected for the relevant blank
**trial injections carried out prior to the run indicated that Samples 1A, 1B, 2A and 2B were well outside the linearity range; therefore, these solutions were not analysed in full
The concentration (g/l) of test material in the sample solutions is shown in the following table:
Table 6.7
Sample Number |
Time shaken at ~ 30ºC (hours) |
Time equilibrated at 20ºC (hours) |
Concentration (g/l) |
Solution pH |
1 |
18¼ |
5 |
~218 |
4.3 |
2 |
18¼ |
5 |
~240 |
4.3 |
Consequently, as the use of the pH 4 buffer had no real effect on the pH of the solutions, it was considered that the effect in the environment would be negligible, essentially due to the low buffering activities seen there.
Definitive test
The mean peak areas relating to the standard and sample solutions are shown in the following table:
Table 6.8
Solution |
Mean peak area |
Standard 30.1 mg/l |
3.877 |
Standard 30.0 mg/l |
3.837 |
Sample 5A |
3.529 |
Sample 5B |
3.498 |
Sample 4A |
3.887 |
Sample 4B |
3.816 |
Sample 3A |
3.798 |
Sample 3B |
3.806 |
Standard 30.1 mg/l |
3.901 |
Standard 30.0 mg/l |
3.842 |
Sample 7A |
3.131 |
Sample 7B |
3.099 |
Sample 6A |
4.319 |
Sample 6B |
4.301 |
Sample 8A |
3.864 |
Sample 8B |
3.877 |
The concentration (g/l) of test material in the sample solutions is shown in the following table:
Table 6.9
Sample Number |
Time shaken at ~ 30ºC (hours) |
Time equilibrated at 20ºC (hours) |
Concentration (g/l) |
Solution pH |
3 |
72 |
24 |
212 |
4.5 |
4 |
48 |
24 |
215 |
4.2 |
5 |
24 |
24 |
196 |
4.2 |
6 |
72 |
24 (30°C) |
239 |
4.3 |
7 |
72 |
24 (10°C) |
173 |
4.2 |
8 |
72 |
24 |
215 |
4.2 |
Consequently, as the use of the pH 9 buffer had no real effect on the pH of the solutions, it was considered that the effect in the environment would be negligible, essentially due to the low buffering activities seen there.
Validation
The linearity of the detector response with respect to concentration was assessed over the nominal concentration range of 0 to 100 mg/l*. This was satisfactory with a correlation coefficient of 1.000 being obtained. This work was performed as part of Harlan Laboratories Ltd Project Number 2920/0020.
*as the orthophosphate anion
Description of key information
One key study exists. The water solubility of potassium dihydrogenorthophosphate was determined according to EU Method A.6 (Water solubility) and under the conditions of GLP.
Key value for chemical safety assessment
- Water solubility:
- 208 g/L
- at the temperature of:
- 20 °C
Additional information
The water solubility of the test material has been determined to be 208 g/l of solution at 20.0 ± 0.5°C.
The effect of temperature over the range 10 to 30°C has been considered not to have had a significant influence on the observed solubility of the test material (range 173 to 239 g/l).
An assessment of the solubility of the test material over the environmentally relevant pH range of 4 to 9 gave solubility results and final solution pH’s similar to those obtained using unbuffered water. Thus, it can be anticipated that the water solubility of the test material over the pH range 4 to 9 would be constant, essentially due to the low buffering activities seen in the environment.
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