Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 257-098-5 | CAS number: 51274-00-1 This substance is identified in the Colour Index by Colour Index Constitution Number, C.I. 77492.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2018-03-19 to 2018-06-15
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- yes
- Remarks:
- Please refer to "Principles of method if other than guideline"
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- 2008
- Principles of method if other than guideline:
- The water solubility of iron hydroxide oxide yellow (Sicovite yellow 10 30 E172) was assessed according to the OECD-Guideline for Testing of Chemicals No. 105, Water Solubility (flask method) with the following modifications:
- Two vessels were set up in a parallel design at 20.0 ± 1.0 °C, each vessel was sampled several times instead of sampling one single vessel at each point in time
- The study was performed under exclusion of atmospheric oxygen and carbon dioxide under inert gas (argon) - GLP compliance:
- yes (incl. QA statement)
- Remarks:
- signed 2016-05-31
- Type of method:
- flask method
- Key result
- Water solubility:
- 1.65 µg/L
- Conc. based on:
- test mat. (dissolved fraction)
- Loading of aqueous phase:
- 200 mg/L
- Incubation duration:
- >= 1 - <= 25 d
- Temp.:
- 20 °C
- pH:
- >= 6.1 - <= 7.1
- Remarks on result:
- other:
- Remarks:
- Filtration through a 0.2 µm membrane and centrifugal filtration (3kDa), Mean of Vessel 1 and 2
- Water solubility:
- 1.02 µg/L
- Conc. based on:
- element (dissolved fraction)
- Loading of aqueous phase:
- 200 mg/L
- Incubation duration:
- >= 1 - <= 25 d
- Temp.:
- 20 °C
- pH:
- >= 6.1 - <= 7.1
- Remarks on result:
- other:
- Remarks:
- Filtration through a 0.2 µm membrane and centrifugal filtration (3kDa), Mean of Vessel 1 and 2
- Water solubility:
- 5.75 µg/L
- Conc. based on:
- test mat.
- Remarks:
- dissolved and dispersed < 0.2 µm
- Loading of aqueous phase:
- 200 mg/L
- Incubation duration:
- >= 1 - <= 25 d
- Temp.:
- 20 °C
- pH:
- >= 6.1 - <= 7.1
- Remarks on result:
- other:
- Remarks:
- Filtration through a 0.2 µm membrane, Mean of Vessel 1 and 2
- Water solubility:
- 3.56 µg/L
- Conc. based on:
- element
- Remarks:
- dissolved and dispersed < 0.2 µm
- Loading of aqueous phase:
- 200 mg/L
- Incubation duration:
- >= 1 - <= 25 d
- Temp.:
- 20 °C
- pH:
- >= 6.1 - <= 7.1
- Remarks on result:
- other:
- Remarks:
- Filtration through a 0.2 µm membrane, Mean of Vessel 1 and 2
- Details on results:
- The iron concentrations of solutions containing iron hydroxide oxide yellow (Sicovit yellow 10 E172) did not appear to increase during the test, and the majority of concentrations was below the LOD or LOQ. Thus, the overall mean iron concentration during the test was calculated based on iron concentrations from day1 to day25, i.e. 3.56 ± 4.51 µg Fe/L for the dissolved/dispersed fraction (0.2 µm filtration), corresponding to 5.75 ± 7.27 µg/L test item. Iron concentrations in the dissolved phase (filtered through a 0.2 µm filter and centrifugally filtered samples) were determined with 1.02 ± 0.21 µg Fe/L, corresponding to 1.65 ± 0.34 µg/L iron hydroxide oxide yellow (Sicovit yellow 10 E172).
- Conclusions:
- Under the conditions of this test (flask method; loading of 200 mg/L), iron concentrations of solutions containing iron hydroxide oxide yellow (Sicovite yellow 10 E172) did not appear to increase during the test, indicating solubility equilibrium. Mean dissolved Fe concentrations after filtration through a 0.2 µm membrane and centrifugal filtration were determined with 1.02 ± 0.21 µg Fe/L, corresponding to 1.65 ± 0.34 µg/L test item in solution.
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP-Guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- yes
- Remarks:
- standard water pH 8 ISO 6341 OECD TGD 29
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Key result
- Water solubility:
- < 1 µg/L
- Temp.:
- 20 °C
- pH:
- 8
- Conclusions:
- insoluble (< 0.1 mg/L)
A very low water solubility was determined according to OECD Guideline 105. With a loading of 10 g iron hydroxide oxide to water at pH 8 the dissolved iron was determined to be <1µg/L (Currenta 2009). - Executive summary:
A very low water solubility of iron hydroxide oxide was determined according to OECD Guideline 105. With a loading of 10 g iron hydroxide oxide to water at pH 8 the dissolved iron was determined to be <1µg/L.
For the determination six test mixtures with two different loading concentrations (1 g/L and 10 g/L) were agitated with a magnetic stirrer for 24 h at 20 °C. The received suspensions were filtrated through a 0.1 µm membrane filter. Also three blank solutions (standard water pH 8 to ISO 6241, OECD-Guidance-Document 29) were investigated. Iron determination was performed in each filtrate by Graphite Furnace Atomic Absorption Spectrometry (GFAAS).
Referenceopen allclose all
Observations
During the study, the respective test items were homogenously distributed in solution. After sampling and filtering, the samples were clear.
Temperature
The mean temperature was 20.6 ± 0.4 °C.
Oxygen concentrations
The oxygen concentration was measured over the period of sampling time inside the acrylic glass box with anMicro IC oxygen sensor (Gfg, Dortmund, Germany). No oxygen was measurable.
pH measurements
Table 1: pH of solutions containing the test item and method blanks
Test items/samples |
Solution pH (min-max) |
||
1d,2dand3d |
8dand9d |
23d,24d and25d |
|
Method Blanks |
5.7–6.0 |
5.9–6.2 |
5.7–5.9 |
SICOVIT®Yellow 10 E172 |
6.1–6.6 |
6.9–7.9 |
6.1–6.8 |
Turbidity measurement
The turbidity of filtered samples from day 1, 2 and 3 was immediately measured after filtering (centrifugal filtration) with a TURB 550 IR (WTW, Weilheim, Germany) to confirm that measured iron concentrations correspond to the dissolved fraction.
The turbidity was below 0.02 NTU, indicating the absence of particles. Due to the limited volume of test solution, turbidity was measured only on day 1, 2 and 3.
Method validation summary (ICP-OES)
Limits of detection (LODs), limits of quantification (LOQs) and correlation coefficients (r)
Limits of detection (LOD) within all measurement series: < 0.938 µg Fe/ L.
Limits of quantification (LOQ) within all measurement series: < 2.81 µg Fe/ L.
Correlation coefficients (r) within all measurement series: >0.99993
Mean recoveries for certified reference materialTMDA-52.4 (concentration range 16.6 – 66.4 µg Fe/L, n=8): 98.4-100%
Mean recoveries for quality control standard (5 µg Fe/ L, n = 4): 99.4 %
Mean recoveries for internal standard (10 µg / L, n = 4): 97.7 %
Mean recovery of fortified samples (n = 20): 98.6 - 104 %
Concentration of Fe < 1 µg/L
Description of key information
A very low water solubility of iron hydroxide oxide yellow was determined according to OECD Guideline 105 over 25 days.
Iron concentrations of solutions containing a loading of 200mg/L iron hydroxide oxide yellow did not appear to increase during the test (25d), indicating solubility equilibrium. Mean dissolved Fe concentrations after filtration through a 0.2 µm membrane and centrifugal filtration were determined 1.02 ± 0.19 µg Fe/L, corresponding to 1.65 ± 0.28 µg/L test item in solution.
Key value for chemical safety assessment
- Water solubility:
- 1.65 µg/L
Additional information
A very low water solubility was determined according to OECD Guideline 105. With a loading of 10 g iron hydroxide oxide to water at pH 8 the dissolved iron was determined to be <1µg/L.
For the determination six test mixtures with two different loading concentrations (1 g/L and 10 g/L) were agitated with a magnetic stirrer for 24 h at 20 °C. The received suspensions were filtrated through a 0.1 µm membrane filter. Also three blank solutions (standard water pH 8 to ISO 6241, OECD-Guidance-Document 29) were investigated. Iron determination was performed in each filtrate by Graphite Furnace Atomic Absorption Spectrometry (GFAAS).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.