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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1973
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions
Cross-reference
Reason / purpose for cross-reference:
reference to other study

Data source

Reference
Reference Type:
other: SIDS Initial Assessment Report
Title:
Stauffer Chemical (1973) in OECD SIDS report 1,2-dichloroethane
Author:
Anonymous
Year:
2002
Bibliographic source:
SIDS Initial Assessment Report for 14th SIAM (Paris, France, March 2002)

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: FDA revision, Fed. Reg. USA, 37, No. 244, 19 Dec. 1972
Deviations:
not specified
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
1,2-dichloroethane
EC Number:
203-458-1
EC Name:
1,2-dichloroethane
Cas Number:
107-06-2
Molecular formula:
C2H4Cl2
IUPAC Name:
1,2-dichloroethane
Details on test material:
1,2-dichloroethane (lot #2100-35.1), a clear colorless liquid.

Test animals

Species:
rabbit
Strain:
not specified
Details on test animals or test system and environmental conditions:
no data

Test system

Type of coverage:
occlusive
Preparation of test site:
not specified
Vehicle:
unchanged (no vehicle)
Controls:
not specified
Amount / concentration applied:
undiluted
Duration of treatment / exposure:
4 hours
Observation period:
96 hours
Number of animals:
6 animals
Details on study design:
0.5 mL of substance was applied under occluded conditions to the intact skin (contact period 4 h, observation time points 4 , 24 and 48 h). Abraded skin was not included. Animals were retained for observation 96 h after initial application.

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
mean
Time point:
other: 4 h
Score:
0
Max. score:
0
Irritation parameter:
erythema score
Basis:
mean
Time point:
24 h
Score:
0
Max. score:
0
Irritation parameter:
erythema score
Basis:
mean
Time point:
48 h
Score:
0
Max. score:
0
Irritation parameter:
erythema score
Basis:
mean
Time point:
72 h
Remarks on result:
not measured/tested
Irritation parameter:
edema score
Basis:
mean
Time point:
other: 4 h
Score:
0
Max. score:
0
Irritation parameter:
edema score
Basis:
mean
Time point:
24 h
Score:
0
Max. score:
0
Irritation parameter:
edema score
Basis:
mean
Time point:
48 h
Score:
0
Max. score:
0
Irritation parameter:
edema score
Basis:
mean
Time point:
72 h
Remarks on result:
not measured/tested
Irritant / corrosive response data:
The test on the intact skin revealed no signs of irritation (scores for all symptoms 0).

Applicant's summary and conclusion

Interpretation of results:
not irritating
Conclusions:
The test on the intact skin revealed no signs of irritation (scores for all symptoms 0).
Executive summary:

In a primary dermal irritation study, 6 rabbits were dermally exposed to 0.5 mL of undiluted 1,2 -dichloroethane for 4 hours. The test substance was applied under occluded conditions to the intact skin. Animals then were observed for 96 h. Irritation was scored at 4, 24 and 48 hours by the method of Draize. The test on the intact skin revealed no signs of irritation (scores for all symptoms 0). Under the condtions of this study, 1,2 -dichloroethane was not irritating to the skin of rabbits.