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EC number: 229-722-6 | CAS number: 6683-19-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1964
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 964
- Report date:
- 1964
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Groups rabbits of either sex were used. A single application of the test material was made at different dose levels. The material was applied to the closely clipped abdominal skin. The test material was moistened with corn oil and spread evenly on a non-absorbent paper backing which was then applied to the skin. The trunks of the animals were wrapped securely with gauze and adhesive tape. After an exposure period of 24 hours, the binders were removed and the area of exposure was washed. The animals were observed for toxic effects and mortality. Throughout the observation period the rabbits were individually housed in elevated metal cages and food and water were freely available at all times. At the end of the observation period each animal was weighed, sacrificed, and examined grossly.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Pentaerythritol tetrakis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate)
- EC Number:
- 229-722-6
- EC Name:
- Pentaerythritol tetrakis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate)
- Cas Number:
- 6683-19-8
- Molecular formula:
- C73H108O12
- IUPAC Name:
- 3-{[3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoyl]oxy}-2,2-bis({[3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoyl]oxy}methyl)propyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate
- Details on test material:
- - Substance type: Organic
- Physical state: Solid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 2.2 - 2.5 kg
- Housing: Individually in elevated metal cages
- Diet (e.g. ad libitum): Ad libitum (Purina Rabbit Chow)
- Water (e.g. ad libitum): Ad libitum
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- corn oil
- Details on dermal exposure:
- TEST SITE
- Area of exposure: Abdomen
- Type of wrap if used: Gauze and adhesive tape
- The areas of exposure of two animals at each level were abraded and the other two remained intact.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): Sponged with warm tap water to remove any sample residue
- Time after start of exposure: 24 h
TEST MATERIAL
- Constant volume or concentration used: no
- For solids, paste formed: yes
VEHICLE
- Amount(s) applied (volume or weight with unit): Enough to moisten the test substance - Duration of exposure:
- 24 h
- Doses:
- 100, 316, 1000, and 3160 mg/kg bw
- No. of animals per sex per dose:
- 2
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: 1, 4, 24 h, and once daily thereafter
- Necropsy of survivors performed: yes
- Other examinations performed: gross examination
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 3 160 mg/kg bw
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- >= 3 160 mg/kg bw
- Mortality:
- None
- Clinical signs:
- other: Normal appearance and behavior
- Gross pathology:
- None
- Other findings:
- Following the removal of the binders at the endo of the exposure period, most or all of the material was still present on the abdomen and the binders of all animals. At the end of the 24h-exposure period, slight erythema was seen in all animals; however, this dermal response completely subsided between the second and the fifth day. For three to seven days during the observation period, slight desquamation was noted on the area of exposure of two animals (one at each level). At termination, there were no signs of dermal irritation in any animal.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The acute dermal LD50 for albino rabbits is greater than 3160 mg/kg of body weight and there was no evidence of systemic toxicity from percutaneous absorption of the test material.
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