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Diss Factsheets
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EC number: 202-327-6 | CAS number: 94-36-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Specific investigations: other studies
Administrative data
- Endpoint:
- biochemical or cellular interactions
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- PubChem BioAssay: 2017 update
- Author:
- Wang Y, Bryant SH, Cheng T, et al.
- Year:
- 2 017
- Bibliographic source:
- Nucleic Acids Research, 45, D955–D963 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5210581/pdf/gkw1118.pdf)
- Reference Type:
- other: Data deposited in or computed by PubChem
- Title:
- PubChem Compound Database; CID=7187
- Author:
- NCBI (National Center for Biotechnology Information)
- Year:
- 2 017
- Bibliographic source:
- https://pubchem.ncbi.nlm.nih.gov/compound/7187 (accessed Apr. 10, 2017)
Materials and methods
- Principles of method if other than guideline:
- The PubChem BioAssay database was searched for chemogenomic, medicinal chemistry and functional genomics biological activities. Assays were retrieved for cell viability and agonist and/or antagonist activities on the peroxisome proliferator-activated receptor alpha (PPARa), delta (PPARd) and gamma (PPARg), androgen receptor (AR), estrogen receptor alpha (ER-alpha), thyroid receptor (TR) and glucocorticoid receptor (GR), p53, vitamin D receptor (VDR), retinoic acid receptor (RAR), farnesoid-X-receptor (FXR), hypoxia (HIF-1), NFkB, RXR, retinoid-related orphan receptor gamma (ROR-gamma), human pregnane X receptor (PXR), constitutive androstane receptor (CAR), retinoid-related orphan receptor gamma (ROR-gamma) and aryl hydrocarbon receptor (AhR) signaling pathways.
- Type of method:
- in vivo
Test material
- Reference substance name:
- Dibenzoyl peroxide
- EC Number:
- 202-327-6
- EC Name:
- Dibenzoyl peroxide
- Cas Number:
- 94-36-0
- Molecular formula:
- C14H10O4
- IUPAC Name:
- diphenylperoxyanhydride
Constituent 1
- Specific details on test material used for the study:
- PubChem CID: 7187
Results and discussion
- Details on results:
- 292 bioassays with 398 bioactivity outcomes were retrieved from the PubChem BioAssay data base. BPO was reported as inactive in 360 outcomes, inconclusive in 14 outcomes and active in 4 outcomes. Results were not specified for 20 outcomes. The 4 active outcomes were not demonstrative of a toxicological activity.
Any other information on results incl. tables
The list of all the assays performed is displayed in the enclosed excel file.
Detailed data on the 4 assays reported as active are displayed below.
Substance ID |
BioAssay name |
Target |
|
268734888 |
AID 1159580; The chemical genetic matrix (CGM) dataset as reported in Wildenhain et al. (2015) Prediction of Synergism from Chemical-Genetic Interactions by Machine Learning. Cell Systems Volume 1, Issue 6, p383-395 |
|
|
103770353 |
AID 1159620; Summary of drug indications. |
|
|
29215306 |
AID 880; qHTS Assay for Inhibitors of RGS12 GoLoco Motif Activity (Red Fluorophore) |
Accession AAC39835; RGS12 [Homo sapiens] |
|
29215306 |
AID 880; qHTS Assay for Inhibitors of RGS12 GoLoco Motif Activity (Red Fluorophore) |
Accession NP_002060; guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 1 [Homo sapiens] |
|
Data for SID 268734888 in AID 1159580
orf |
YJR066W |
sym |
TOR1 |
raw OD read 1 |
0.8179 |
raw OD read 2 |
0.8173 |
normalized OD average |
0.819912 |
z_score |
-4.15444 |
p_value |
0.0000164596 |
non replicate |
0 |
cryptagen |
0 |
bioactivity |
sensitive |
Data for SID 103770353 in AID 1159620
First Approval |
1984 |
MeSH ID |
D000152 |
MeSH Heading |
ACNE VULGARIS |
EFO ID |
EFO:00038 |
EFO Term |
ACNE |
Max Phase for Indication |
4 |
References |
DailyMed |
Data for SID 29215306 in AID 880
Phenotype |
Inhibitor |
Potency [uM] |
35.4813 |
Efficacy [%] |
91.4035 |
Curve_Description |
Partial curve; high efficacy |
Fit_LogAC50 |
-4.45 |
Fit_HillSlope |
1.5386 |
Fit_R2 |
0.9583 |
Fit_InfiniteActivity [%] |
-168.96 |
Fit_ZeroActivity [%] |
-77.5565 |
Fit_CurveClass |
-2.1 |
Excluded_Points |
0 0 0 0 0 |
Max_Response [%] |
-140.8 |
Activity at 0.094 uM [%] |
-68.71 |
Activity at 0.551 uM [%] |
-82.58 |
Activity at 2.4054 uM |
-83.62 |
Activity at 14.16 uM [%] |
-90.07 |
Activity at 61.64 uM [%] |
-140.8 |
Compound QC |
QC'd by "Labotest" |
Data for SID 29215306 in AID 880
Phenotype |
Inhibitor |
Potency [uM] |
35.4813 |
Efficacy [%] |
91.4035 |
Curve_Description |
Partial curve; high efficacy |
Fit_LogAC50 |
-4.45 |
Fit_HillSlope |
1.5386 |
Fit_R2 |
0.9583 |
Fit_InfiniteActivity [%] |
-168.96 |
Fit_ZeroActivity [%] |
-77.5565 |
Fit_CurveClass |
-2.1 |
Excluded_Points |
0 0 0 0 0 |
Max_Response [%] |
-140.8 |
Activity at 0.094 uM [%] |
-68.71 |
Activity at 0.551 uM [%] |
-82.58 |
Activity at 2.4054 uM |
-83.62 |
Activity at 14.16 uM [%] |
-90.07 |
Activity at 61.64 uM [%] |
-140.8 |
Compound QC |
QC'd by "Labotest" |
Applicant's summary and conclusion
- Executive summary:
The PubChem BioAssay database was searched for chemogenomic, medicinal chemistry and functional genomics biological activities. 292 bioassays with 398 bioactivity outcomes were retrieved from the PubChem BioAssay data base. BPO was reported as inactive in 360 outcomes, inconclusive in 14 outcomes and active in 4 outcomes. Results were not specified for 20 outcomes. The 4 active outcomes were not demonstrative of a toxicological activity. Therefore, BPO appearred to be devoied of activity in cell viability assays, and of agonist and/or antagonist activities on the peroxisome proliferator-activated receptor alpha (PPARa), delta (PPARd) and gamma (PPARg), androgen receptor (AR), estrogen receptor alpha (ER-alpha), thyroid receptor (TR) and glucocorticoid receptor (GR), p53, vitamin D receptor (VDR), retinoic acid receptor (RAR), farnesoid-X-receptor (FXR), hypoxia (HIF-1), NFkB, RXR, retinoid-related orphan receptor gamma (ROR-gamma), human pregnane X receptor (PXR), constitutive androstane receptor (CAR), retinoid-related orphan receptor gamma (ROR-gamma) and aryl hydrocarbon receptor (AhR) signaling pathways.
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