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EC number: 211-074-0 | CAS number: 629-11-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
1,6 Hexanediol is neither irritating to the skin nor irritating to the eye. From the available information it is concluded that 1,6 hexanediol is not irritating to the respiratory tract.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Irritation to skin was analyzed in a study, where ca. 1 ml of 80% 1,6-hexanediol was applied to the intact back skin of two Vienna
White rabbits for 1, 5, 15 minutes and 20 hours (BASF, 1961). After the exposure period, the application site was washed with Lutrol and Lutrol/water followed by an observation period of 72 hours. Since the evaluation of the application sites resulted in
erythema and edema scores of 0, no signs of skin irritation was found.
The results of the key study are confirmed by other studies. Since an overall irritation score of two out of ten was found after an open application of 1,6-hexanediol to rabbit skin (Carpenter, 1974).
In a study with pigs, three animals received application of 0.2 ml 1,6-hexanediol at a concentration of 45% to the shaved skin for 24
hours (Kurihara, 1996). When sites were evaluated using the criteria of the International Contact Dermatitis Research Group, no primary skin irritation was observed.
The potential of 1,6-Hexanediol to cause damage to the conjunctiva, iris or cornea was assessed in a study according to OECD 405 (BASF 2016) by a single ocular application of 0.1 mL of the undiluted heated and then cooled down test item to one eye of three New Zealand White rabbits (stepwise procedure starting with one animal and supplementing two additional animals). About, and not less than 24 hours after application the eye was rinsed with tap water. The following test item-related clinical observations were recorded during the course of the study: no corneal lesions detectable; moderate iritis (grade 1); slight to obvious conjunctival redness (grade 1-2); slight to moderate conjunctival chemosis (grade 1-2); slight to obvious discharge (grade 1-2). Additional findings like desquamation of corneal epithelium and injected scleral vessels in a circumscribed or circular area were noted in the animals within 48 or 72 hours after application. The ocular reactions were reversible in all animals within 7 days after application. Considering the described ocular reactions as well as the average score for irritation, 1,6 -hexandiol does not show an eye irritating potential under the test conditions chosen.
Irritation to eyes was evaluated in a study, where 50 mg 1,6-hexanediol was instilled into the eyes of Vienna White rabbits (BASF, 1961). As result, some minor effects were noted, but they disappeared within the five day observation period, so that the scores for corneal opacity, conjunctival chemosis and erythema were 1, 0.2 and 1, respectively. Thus, 1,6-hexanediol was found to be not irritant to eyes.
Justification for classification or non-classification
Classification is not warranted according to the criteria of EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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