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EC number: 249-079-5 | CAS number: 28553-12-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- No data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- A 1968 non-GLP study report without guidelines specified. However, the report contains the essential elements for an acute dermal toxicity study and there were sufficient data reported to come to a conclusion. The level of information reported for systemic toxicity parameters was minimal.
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 968
- Report date:
- 1968
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Although no guideline appears to have been followed, the study was undertaken as a classical LD50 determination
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 1,2-Benzenedicarboxylic acid, di-C8-10-branched alkyl esters, C9-rich
- EC Number:
- 271-090-9
- EC Name:
- 1,2-Benzenedicarboxylic acid, di-C8-10-branched alkyl esters, C9-rich
- Cas Number:
- 68515-48-0
- Molecular formula:
- C26 H42 O4
- IUPAC Name:
- 1,2-Benzenedicarboxylic acid, di-C8-10-branched alkyl esters, C9-rich
- Reference substance name:
- DINP
- IUPAC Name:
- DINP
- Details on test material:
- An organic ester; clear, slightly viscous liquid with an unpleasant odour received on 25 March 1968
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: No data
- Age at study initiation: Adult
- Weight at study initiation: 2.0-2.8 kg
- Fasting period before study: No evidence of fasting
- Housing: No data
- Diet (e.g. ad libitum): Purina rabbit chow. ad libitum
- Water (e.g. ad libitum): Ad libitum
- Acclimation period: No data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): No data
- Humidity (%): No data
- Air changes (per hr): No data
- Photoperiod (hrs dark / hrs light): No data
IN-LIFE DATES: No data
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- corn oil
- Details on dermal exposure:
- TEST SITE
- Area of exposure: Abdominal skin; no area reported
- % coverage: No data
- Type of wrap if used: Rubber dam binder wrapped with gauze and sticky tape
REMOVAL OF TEST SUBSTANCE
- Washing (if done): Water
- Time after start of exposure: 24 hours after exposure
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): No data-must have been variable volume dosage
- Concentration (if solution): 10% vol/vol or undiluted
- Constant volume or concentration used: constant concentration or undiluted
- Duration of exposure:
- 24 hours
- Doses:
- 50, 200, 754 and 3,160 mg/kg body weight
- No. of animals per sex per dose:
- 4
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Immediately, 1, 4 and 24 hours after dosing, and once daily thereafter. Bodyweights initially and terminally
- Necropsy of survivors performed: Yes - Statistics:
- Not necessary
Results and discussion
- Preliminary study:
- No data
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 3 160 mg/kg bw
- Mortality:
- No deaths
- Clinical signs:
- other: other: No evidence of systemic toxicity at any dosage.
- Gross pathology:
- No remarkable findings
- Other findings:
- Skin reactions generally consisted of moderate erythema at 24 hours, which diminished and completely subsided at all levels by Day 6, and slight desquamation in two to four animals, which disappeared by Day 12.
Any other information on results incl. tables
No tables or appendices on mortality, clinical signs, bodyweight or necropsy observations were reported. Dermal reactions at the application site are attached in the 'Overall remarks, and attachments' window below.
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- The acute dermal LD50 for rabbits of either sex was > 3160 mg/kg. Skin reactions generally consisted of moderate erythema at 24 hours which diminished and completely subsided at all levels by Day 6, and slight desquamation in two to four animals which disappeared by Day 12.
- Executive summary:
In an acute dermal toxicity study, rabbits of either sex (New Zealand White) were given a single occluded dermal dose of MRD 68-28 in corn oil to the clipped abraded abdominal skin at nominal dosages of 50, 200, 754 or 3160 mg/kg. There were no deaths or no evidence of systemic toxicity observed during the subsequent 14-day observation period. Skin reactions generally consisted of moderate erythema at 24 hours which diminished and completely subsided at all levels by Day 6, and slight desquamation in two to four animals which disappeared by Day 12. Based on these results, the LD50 of MRD 68-28 was greater than 3160 mg/kg.
The toxicity study is considered acceptable for classification, and essentially satisfies the guideline requirements for rabbit acute dermal toxicity studies. The level of information reported for systemic toxicity parameters was minimal.
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