Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 212-485-8 | CAS number: 822-06-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
Skin irritation
In a dermal irritation/corrosion study HDI was corrosive to the skin of rabbits according to OECD TG 404 (Schreiber, 1981). Immediately after patch removal all treated animals showed severe edema and erythema (grade 4). 24 hours after patch removal induration and necrosis at the application site of all animals were seen. No reversibility could be observed at the end of the post-observation period of 8 days.
Eye irritation
In an acute eye irritation/corrosion study HDI was corrosive to the eyes of rabbits according to OECD TG 405 (Schreiber, 1981). The examination of the eyes showed 1 hour after instillation severe effects in all animals with regard to cornea, iris and conjunctivae (left eye not rinsed). All effects had a tendency to get worse during the 8-day post-observation period. Damage to the eye was already observed 30 seconds after instillation (right eye rinsed with saline 30 sec. after instillation).
Respiratory / sensory irritation
Sensory irritation studies using laboratory animal models demonstrated evidence of sensory irritation but no evidence of pulmonary irritation to HDI. In a sensory irritation study with HDI vapour Sangha et al. (1981) reported a 3-hour RD50 (concentration required to reduce respiratory rate by 50 %) of 1.19 mg/m3 using male Swiss Webster mice. Exposure duration between 0.17-3 hours and concentrations between 1.19 -6.71 mg/m3 caused a time and concentration dependent decrease of the respiration rate. Fast recovery
after short exposure and slow recovery after longer exposure were observed. A comparable study using male Fisher 344 rats resulted in a 30-minute RD50 of 9.93 mg/m3 (Sangha, 1982). HDI vapour exposure (head-only) of female Sprague-Dawley rats revealed a 3-hour RD50 of 11.83 mg/m3 (1.69 ppm) (Shiotsuka 1987a). In a study to assess the effects of repeated exposures on respiratory rate, female Sprague-Dawley rats were head-only exposed 3 hours/day for 6 days (5 consecutive days and 2 days later for an additional day) to a mean HDI vapour concentration of 8.19 mg/m3 (1.17 ppm). The daily decrease in respiratory rate of 50 to 63 %, relative to pre-exposure mean for day 1, showed that repeated exposures did not produce a cumulative effect on respiratory rate depression during daily exposures (Shiotsuka, 1987b).
Justification for classification or non-classification
Skin irritation
Classified under Annex I of Directive 67/548/EEC with R38 (irritating to skin). This classification corresponds to Category 2 (causes skin irritation) according to Annex VI-1 of Regulation (EC) No 1272/2008. Differing from this the irreversible damage to the skin of rabbits leads to the following classification according to Annex I of Regulation (EC) No 1272/2008: Category 1C (H314: Causes severe skin burns and eye damage).
Eye irritation
Classified under Annex I of Directive 67/548/EEC with R36 (irritating to eye). This classification corresponds to Category 2 (causes serious eye irritation) according to Annex VI-1 of Regulation (EC) No 1272/2008. Differing from this the irreversible damage to the eyes of rabbits leads to the following classification according to Annex I of Regulation (EC) No 1272/2008: Category 1C (H314: Causes severe skin burns and eye damage).
Respiratory irritation
Classified under Annex I of Directive 67/548/EEC with R37 (irritating to respiratory system). This classification corresponds to STOT-SE Category 3 (H335: May cause respiratory irritation) according to Annex VI-1 of Regulation (EC) No 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.