Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-854-4 | CAS number: 111-29-5
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
Gessner (1960):
In an available metabolism study, four Chinchilla rabbits received applications of 2 mmol/kg bw pentane-1,5-diol by gavage. As results, no glucuronic acid conjugates of the test substance were found, but glutaric acid was characterized as urinary metabolite.
It was also stated, that the unchanged test substance was not found in the urine.
Plapp (2015):
in vitro:
The metabolites of 1,5-pentanediol by horse liver ADH1E-activity were analyzed by gas chromatography. No significant increase in 5-hydroxypentanal or d-valerolactone concentrations was detected. Nevertheless, the enzymatic reaction of ADH1E with 5-hydroxypentanal showed that d-valerolactone and 1,5-pentanediol formed slowly in approximately equal concentrations (2 mM each at 12 h), in a dismutation reaction that consumed little NAD+.
in vivo:
In rats the contribution of liver alcohol dehydrogenase (ADH) to the metabolism of alcohols was investigated by using inhibitors of ADH.
After intraperitoneal injection of 10 mmol/kg 1,5-pentanediol was eliminated by zero order kinetics. Furthermore d-valerolactone was identified as metabolite, formed by oxidation of 1,5-pentanediol. Blood levels of about 5 mM d-valerolactone were detected in one to two hours before clearing by six hours. It appears that aldehyde dehydrogenases are involved in the metabolism of 1,5-pentanediol because the oxidation of 5-hydroxypentanal by ADH1E to d-valerolactone in vitro was relatively slow.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
