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Diss Factsheets
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EC number: 500-101-4 | CAS number: 38294-64-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
No toxicokinetic studies have been conducted on this substance. The corrosive nature of the material precludes toxicokinetic testing due to animal welfare considerations. However, similar substances such as Bisphenol A diglycidyl ether (BADGE) have been studied extensively.
Absorption following dermal exposure to BADGE is low, with most of the dose (66%) remaining at the application site and/or its covering. Oral absorption of 14C-BADGE is high, but further studies indicate that the material is not stable in gastric fluid and is likely degraded either in the stomach or first-pass toxicokinetics through the liver. Metabolite profiles indicate rapid degradation by epoxide hydrolases in liver and lung, and comparative toxicokinetic studies indicate that human microsomes are more efficient in degrading BADGE than rodent microsomes.
Although this material has been demonstrated in QSAR assessments to contain no hydrolysable groups, the chemical structure indicates, similar to BADGE, the material is not stable in gastric fluid and is likely degraded either in the stomach or first-pass toxicokinetics through the liver.
Key value for chemical safety assessment
Additional information
No toxicokinetic studies have been conducted on this substance. The corrosive nature of the material precludes toxicokinetic testing due to animal welfare considerations. However, similar substances such as Bisphenol A diglycidyl ether (BADGE) have been studied extensively.
Absorption following dermal exposure to BADGE is low, with most of the dose (66%) remaining at the application site and/or its covering. Oral absorption of14C-BADGE is high, but further studies indicate that the material is not stable in gastric fluid and is likely degraded either in the stomach or first-pass toxicokinetics through the liver. Metabolite profiles indicate rapid degradation by epoxide hydrolases in liver and lung, and comparative toxicokinetic studies indicate that human microsomes are more efficient in degrading BADGE than rodent microsomes.
Although this material has been demonstrated in QSAR assessments to contain no hydrolysable groups, the chemical structure indicates, similar to BADGE, the material is not stable in gastric fluid and is likely degraded either in the stomach or first-pass toxicokinetics through the liver.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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