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EC number: 202-708-7 | CAS number: 98-86-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: ; study acceptable as supporting information
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxicité et pouvoir hypnotique de l'acetophenone et des thienylketones (French). (Toxicity and hypnotic potential of acetophenone and thienylketones)
- Author:
- Quevauviller A
- Year:
- 1 946
- Bibliographic source:
- C R Soc Biol Année 1946: 367-369
Materials and methods
- Principles of method if other than guideline:
- Acetophenone was applied by intrapertioneal injection and clinical symptoms and mortality was investigated
Test material
- Reference substance name:
- Acetophenone
- EC Number:
- 202-708-7
- EC Name:
- Acetophenone
- Cas Number:
- 98-86-2
- Molecular formula:
- C8H8O
- IUPAC Name:
- 1-phenylethanone
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- male
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- olive oil
- Doses:
- range from < 400 mg/kg bw to > 700 mg/kg bw
- No. of animals per sex per dose:
- 7-8
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1 070 mg/kg bw
- Sex:
- male
- Dose descriptor:
- LD100
- Effect level:
- 1 600 mg/kg bw
Any other information on results incl. tables
Clinical symptoms:
400 - 500 mg/kg: within 5 min staggering gait, within 13 min paraparesis, within 20 min tetraparesis
700 mg/kg: maximum tolerable dose
> 700 mg/kg: death occurring more or less rapid by respiratory depression
Applicant's summary and conclusion
- Conclusions:
- For intraperitoneal application the maximal tolerable dose was found to be 700 mg/kg bw in mice. At higher concentrations death occured by respiratory depression with a LD50 of 1,070 mg/kg and a LD100 of 1,600 mg/kg. The target of the acute toxic action of acetophenone was the nervous system.
- Executive summary:
Acetophenone was applied by intraperitoneal injection (vehicle olive oil) to mice and clinical symptoms and mortality was investigated. In the dose range of 400-500 mg/kg depression of the nervous system occurred within 5 min indicated by symptoms as staggering gait followed by paraparesis and tetraparesis. The maximal tolerable dose was found to be 700 mg/kg bw. At higher concentrations death occured by respiratory depression with a LD50 of 1,070 mg/kg and a LD100 of 1,600 mg/kg.
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