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Diss Factsheets
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EC number: 201-134-4 | CAS number: 78-70-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- No data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Remarks:
- Study not conducted according to international guideline, but performed under standardized conditions. No data on whether study was conducted under GLP.
Data source
Reference
- Reference Type:
- publication
- Title:
- Fragrance Compounds and Essential Oils with Sedative Effects upon Inhalation
- Author:
- Buchbauer G, Jirovetz L, Jäger W, Plank C and Dietrich H
- Year:
- 1 993
- Bibliographic source:
- Journal of Pharmaceutical Sciences, Vol. 82, No. 6, pp 660-664, June 1993
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Mice were exposed to linalool in air under standardized conditions, and the effect on motility was determined. In addition blood samples were drawn 0m 30, 60 & 90 minutes after inhalation and plasma was analysed by GC-MS, GC-FTIR & GC-FID for the presence of linalool.
- GLP compliance:
- no
- Test type:
- other: Inhalation study under standardized conditions
- Limit test:
- no
Test material
- Reference substance name:
- Linalool
- EC Number:
- 201-134-4
- EC Name:
- Linalool
- Cas Number:
- 78-70-6
- Molecular formula:
- C10H18O
- IUPAC Name:
- 3,7-dimethylocta-1,6-dien-3-ol
- Details on test material:
- - Name of test material (as cited in study report): Linalool
- Substance type: fragrance compound
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- Swiss
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: No data
- Age at study initiation: 6-8 week and 6 months old
- Weight at study initiation: 28.5 g
- Housing: In groups of 4 on a bedding of wood shavings in polycarbonate cages (Makrolon, type II)
- Diet: Standardized pelleted food T 799 (Tagger, Graz, Austria) ad libitum
- Water: Ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 2°C
- Humidity (%): 60 ± 10%
- Air changes (per hr): 12-15
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- other: experimental procedure according to Kovar et al. (1987) and technical characteristics according to Buchbauer et al. (1992)
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- No data
- Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- To calculate the air concentration of the fragrance compounds in the cage to determine the total drug volume (20-50 mg per compound), the charcoal tubes (120, NIOSH, Catalogue no. 226-01) supplied by Drager Company, Lübeck, Germany were used.
- Duration of exposure:
- 1 h
- Concentrations:
- No data
- No. of animals per sex per dose:
- No data
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: minimum 10 minutes
- Frequency of observations and weighing: no data
- Necropsy of survivors performed: no data
- Other examinations performed: the motility of the mice was examined. - Statistics:
- Statistics were calculated with an Atari 1040 personal computer (WISTAT scientific statistic package program). Significance was determined by the t test and F-test; the level of significance chosen for p to reject the null hypothesis was <0.05.
Results and discussion
- Preliminary study:
- Not relevant
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LC50
- Effect level:
- > 20 other: mg
- Exp. duration:
- 1 h
- Remarks on result:
- other: no deaths after exposure to 20-50 mg linalool
- Mortality:
- No data
- Clinical signs:
- other: The exposure led to a decrease in motility of the mice. After a 1-h inhalation period, the motility of mice exposed to linalool was 73% lower than the motility of the untreated control animals.
- Body weight:
- No data
- Gross pathology:
- No data
- Other findings:
- No data
Any other information on results incl. tables
The concentration of linalool in the blood samples following inhalation was 4.22 ng/mL.
Applicant's summary and conclusion
- Interpretation of results:
- other: causes a decrease in motility in mice
- Remarks:
- Criteria used for interpretation of results: other: no criteria used
- Conclusions:
- Linalool caused a decrease in motility in mice of 73% when exposed to 20-50 mg compound in a 1-hour inhalation study.
- Executive summary:
The influence of linalool on the motility in mice was tested in an inhalation study under standardized conditions. After a 1 -hour inhalation period, the motility in the exposed mice was decreased by 73% compared to the motility of untreated control animals. No deaths were reported at the concentration tested (20 -50 mg).
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