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Diss Factsheets
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EC number: 244-787-0 | CAS number: 22113-87-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Does not meet important criteria of today standard methods
Data source
Reference
- Reference Type:
- publication
- Title:
- Cutaneous toxicity of liquified methylamine gas
- Author:
- Goffman T, Maguire HC Jr
- Year:
- 1 980
- Bibliographic source:
- Contact Dermatitis. 1980 Jan;6(2):140-1
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Liquified methylamine was dropped on the skin of guinea pigs and histological observations were made during 12 days
- GLP compliance:
- no
Test material
- Reference substance name:
- Monomethylamine
- IUPAC Name:
- Monomethylamine
- Details on test material:
- - Name of test material (as cited in study report): Monomethylamine or aminomethane
- Physical state: gas
Constituent 1
Test animals
- Species:
- guinea pig
- Strain:
- Hartley
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 500 g
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- other: clipped
- Controls:
- yes
- Amount / concentration applied:
- 3 drops of methylamine/site
- Duration of treatment / exposure:
- 12 d (single application but no washing was made)
- Observation period:
- 12 d
- Number of animals:
- 3 experimental animals
2 control animals
Results and discussion
In vivo
Results
- Remarks on result:
- other: No quantitative indicator was provided
- Irritant / corrosive response data:
- Immediately after exposure: skin color change
Within a few minutes: swollen and suffused skin with a dull purple hue
Within 48 hr: necrotic skin (keratinous debris in the epidermis, disorganized collagen, hemorrhage, massive infiltrate of round cells and polymorphonuclear leukocytes in the dermis)
Within 12 days: flat epidermis, fresh granulation the dermis, no hair follicles
Any other information on results incl. tables
The authors were surprised by the extent and rapidity of the injury, so there was not time to effectively wash away the material
Applicant's summary and conclusion
- Interpretation of results:
- highly corrosive
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- Despite the fact it was a non guideline study, liquified methylamine was proved to be very corrosive to the skin of guinea pigs.
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