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Diss Factsheets
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EC number: 231-749-3 | CAS number: 7719-12-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Older, non-GLP proprietary study.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Non-standard acute dermal toxicity study
- GLP compliance:
- no
- Remarks:
- : study pre-dates GLP
- Test type:
- other: non-standard design
- Limit test:
- no
Test material
- Reference substance name:
- Phosphorus trichloride
- EC Number:
- 231-749-3
- EC Name:
- Phosphorus trichloride
- Cas Number:
- 7719-12-2
- Molecular formula:
- Cl3P
- IUPAC Name:
- phosphorus trichloride
- Reference substance name:
- supplier code
- IUPAC Name:
- supplier code
- Details on test material:
- No further details are reported
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- The animals were immobilised in an animal holder and their backs clipped free of hair, approximately 10% of each animal's skin surface.
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- One half of the animals were further prepared by making epidermal abrasions every 2 or 3 centimeters over the area of exposure. The abrasions were made sufficiently deep to penetrate the stratum corneus, bu not deep enough to disturb the dermo. The test material was administered dermally on a g/kg basis.
- Duration of exposure:
- Not reported
- Doses:
- A dose of 0.25 g/kg bw was administered to 12 rabbits. Two further animals were used in a range-finding study in which doses of 0.5 g/kg bw and 0.25 g/kg were administered.
- No. of animals per sex per dose:
- 12 (main study)
- Control animals:
- no
- Details on study design:
- Forteen male rabbits were used in this experiment. One half of the animals were further prepared by making epidermal abrasions every 2 or 3 centimeters over the area of exposure. The abrasions were made sufficiently deep to penetrate the stratum corneus, bu not deep enough to disturb the dermo. The test material was administered dermally on a g/kg basis. A dose of 0.25 g/kg was administered to 12 rabbits. Two further animals were used and doses of 0.5 g/kg and 0.25 g/kg administered.
- Statistics:
- None available
Results and discussion
- Preliminary study:
- Not relevant
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 250 - < 500 mg/kg bw
- Remarks on result:
- other: 1/1 death at 500 mg/kg bw; 0/13 deaths at 250 mg/kg bw
- Mortality:
- At a dose level of 0.5 g/kg there was one animal death per level. There were no mortalities at 0.25 g/kg.
- Clinical signs:
- other: Edema, erthema, necrosis and eschar were observed at both 0.25 g/kg and 0.5 g/kg.
- Gross pathology:
- no autopsies conducted
- Other findings:
- No other findings
Any other information on results incl. tables
Deaths occurred at 500 mg/kg bw (1/1); no deaths occured at 250 mg/kg bw (0/13). Local effects (oedema, erythema, eschar and necrosis) were observed at the application site in all animals.
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute dermal LD50 is estimated to be between 250 -500 mg/kg bw, but is considered likely to be closer to 500 mg/kg bw.
- Executive summary:
The test material was applied to the shorn dorsal skin of male New Zealand White Rabbits for an unspecified period of time. Dose levels of 250 and 500 mg/kg bw (1/ rabbit) were used in a range-finding study. In the main study, twelve rabbits were used at a dose level of 250 mg/kg bw; the skin was abraded in half of these animals.
The single animal administered 500 mg/kg bw died. Signs of local severe irritation/corrosion were observed in all animals.
The acute dermal LD50 of the test material is estimated to be between 250 -500 mg/kg bw.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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