Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 295-442-6 | CAS number: 92045-60-8 A complex combination of hydrocarbons obtained by subjecting a petroleum naphtha to a sweetening process to convert mercaptans or to remove acidic impurities. It consists of hydrocarbons having carbon numbers predominantly in the range of C4 through C5, predominantly C5, and boiling in the range of approximately minus 10°C to 35°C (14°F to 95°F).
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Toxicological Summary
- Administrative data
- Workers - Hazard via inhalation route
- Workers - Hazard via dermal route
- Workers - Hazard for the eyes
- Additional information - workers
- General Population - Hazard via inhalation route
- General Population - Hazard via dermal route
- General Population - Hazard via oral route
- General Population - Hazard for the eyes
- Additional information - General Population
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 1 286.4 mg/m³
- Most sensitive endpoint:
- neurotoxicity
- Route of original study:
- By inhalation
DNEL related information
- DNEL derivation method:
- other: ECHA REACH guidance procedure but incorporating CONCAWE/ECETOC inter/intra species AF
- Overall assessment factor (AF):
- 9
- Dose descriptor starting point:
- LOAEC
- Value:
- 4 320 mg/m³
- Modified dose descriptor starting point:
- LOAEC
- Value:
- 11 577.6 mg/m³
- Explanation for the modification of the dose descriptor starting point:
60 mins exposure adjusted for duration of work [60/15 {mins of work} x 6.7/10 {light work ventilation rate}]
- AF for dose response relationship:
- 3
- Justification:
- LOAEL adjusted to NOAEL using ECHA R.8 and ECETOC 'non-severe'.
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- Allometric scaling not required
- AF for other interspecies differences:
- 1
- Justification:
- Not applicable, human study
- AF for intraspecies differences:
- 3
- Justification:
- ECETOC intraspecies AF
- AF for the quality of the whole database:
- 1
- Justification:
- Reliable human dataset (only data available)
- AF for remaining uncertainties:
- 1
- Justification:
- Not required
Local effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 837.5 mg/m³
- Most sensitive endpoint:
- irritation (respiratory tract)
DNEL related information
- DNEL derivation method:
- other: ECHA REACH guidance procedure but incorporating CONCAWE/ECETOC inter/intraspecies AF
- Overall assessment factor (AF):
- 6
- Dose descriptor:
- NOAEC
- Value:
- 5 025 mg/m³
- AF for dose response relationship:
- 1
- Justification:
- Not required, starting point was a NOAEL
- AF for differences in duration of exposure:
- 2
- Justification:
- Subchronic to chronic, ECHA R.8 value
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- Allometric scaling not required
- AF for other interspecies differences:
- 1
- Justification:
- Effects at the membrane level such as chemical irritation are considered similar in all species
- AF for intraspecies differences:
- 3
- Justification:
- ECETOC intraspecies AF
- AF for the quality of the whole database:
- 1
- Justification:
- Reliable study available
- AF for remaining uncertainties:
- 1
- Justification:
- Not required
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 1 066.67 mg/m³
- Most sensitive endpoint:
- irritation (respiratory tract)
DNEL related information
- DNEL derivation method:
- other: ECHA REACH guidance procedure but incorporating CONCAWE/ECETOC inter/intraspecies AF
- Overall assessment factor (AF):
- 9
- Dose descriptor starting point:
- LOAEC
- Value:
- 9 600 mg/m³
- AF for dose response relationship:
- 3
- Justification:
- Starting point LOAEL adjusted to NOAEL (ECHA R.8 value)
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- Allometric scaling not required
- AF for other interspecies differences:
- 1
- Justification:
- Not required; human study
- AF for intraspecies differences:
- 3
- Justification:
- ECETOC intrapsecies AF
- AF for the quality of the whole database:
- 1
- Justification:
- Reliable human dataset
- AF for remaining uncertainties:
- 1
- Justification:
- Not required
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- low hazard (no threshold derived)
Acute/short term exposure
- Hazard assessment conclusion:
- low hazard (no threshold derived)
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - workers
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 1 152 mg/m³
- Most sensitive endpoint:
- neurotoxicity
- Route of original study:
- By inhalation
DNEL related information
- DNEL derivation method:
- other: ECHA REACH guidance procedure but incorporating Concawe/ECETOC inter/intra species AF
- Overall assessment factor (AF):
- 15
- Dose descriptor starting point:
- LOAEC
- Value:
- 4 320 mg/m³
- Modified dose descriptor starting point:
- LOAEC
- Value:
- 17 280 mg/m³
- Explanation for the modification of the dose descriptor starting point:
Starting point 4320, 60 mins exposure adjusted for duration of work [60/15 {mins of work}] = 17280 mg/m3
- AF for dose response relationship:
- 3
- Justification:
- LOAEL adjusted to NOAEL using ECHA R.8 and ECETOC 'non-severe'.
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- Allometric scaling not required
- AF for other interspecies differences:
- 1
- Justification:
- Not applicable, human study
- AF for intraspecies differences:
- 5
- Justification:
- ECETOC intraspecies AF
- AF for the quality of the whole database:
- 1
- Justification:
- Reliable study available
- AF for remaining uncertainties:
- 1
- Justification:
- Not requried
Local effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 178.57 mg/m³
- Most sensitive endpoint:
- irritation (respiratory tract)
DNEL related information
- DNEL derivation method:
- other: 'ECHA REACH guidance procedure but incorporating CONCAWE/ECETOC intra/interspecies AF
- Overall assessment factor (AF):
- 10
- Dose descriptor:
- NOAEC
- Value:
- 1 786 mg/m³
- AF for dose response relationship:
- 1
- Justification:
- Not required, starting point was a NOAEL
- AF for differences in duration of exposure:
- 2
- Justification:
- Sub-chronic to chronic; ECHA R.8 value
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- Allometric scaling not required
- AF for other interspecies differences:
- 1
- Justification:
- Effects at the membrane level such as chemical irritation are considered similar in all species
- AF for intraspecies differences:
- 5
- Justification:
- ECETOC intrapsecies AF
- AF for the quality of the whole database:
- 1
- Justification:
- reliable study available
- AF for remaining uncertainties:
- 1
- Justification:
- Not requried
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 640 mg/m³
- Most sensitive endpoint:
- irritation (respiratory tract)
DNEL related information
- DNEL derivation method:
- other: ECHA REACH guidance procedure but incorporating CONCAWE/ECETOC intra/interspecies AF
- Overall assessment factor (AF):
- 15
- Dose descriptor starting point:
- LOAEC
- Value:
- 9 600 mg/m³
- AF for dose response relationship:
- 3
- Justification:
- Starting point LOAEL adjusted to NOAEL (ECHA R.8 value)
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- Allomteric scaling not required
- AF for other interspecies differences:
- 1
- Justification:
- Not required, human study
- AF for intraspecies differences:
- 5
- Justification:
- ECETOC intraspecies AF
- AF for the quality of the whole database:
- 1
- Justification:
- Reliable human dataset
- AF for remaining uncertainties:
- 1
- Justification:
- Not required
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- low hazard (no threshold derived)
Acute/short term exposure
- Hazard assessment conclusion:
- low hazard (no threshold derived)
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - General Population
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
![ECHA](/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/echa_logo.png)