Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 215-686-9 | CAS number: 1344-08-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The oral LD50 for Na2Sx is 85.8 (95% CI 73.8 - 99.6) mg/kg bw.
The dermal LD50 Na2Sx is 590 mg/kg bw.
An inhalation study was not performed and an LD50 is not available.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 85.8 mg/kg bw
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 590 mg/kg bw
Additional information
For acute toxicity endpoints data from disodium tetrasulfide and disodium disulfide is used, for further justification see attached document.
The oral LD50 for disodium tetrasulfide is 130 mg/kg bw (95% CI 81 -180) for males and 128 mg/kg bw (95% CI 66 -324) for females.
The oral LD50 for disodium disulfide is 82.5 (95% CI 60.8 - 112) mg/kg bw for males and 92.8 (95% CI 68.8 - 127) mg/kg bw for females. Combined the LD50 is 85.8 (95% CI 73.8 - 99.6) mg/kg bw.
The dermal LD50 for disodium tetrasulfide in female animals was estimated at 590 mg/kg bw. The LD50 for males was estimated at 1650 mg/kg bw.
For disodium disulfide determination of a dermal LD50 value was impossible, because of the limited number of animals used in the study (2 animals). One animal was found dead at the end of the day of dosing and the second animal was killed after 24 hours because of the corrosion to the skin that was observed. Further testing is unjustified due to the corrosive properties of the test substance.
An inhalation study was not performed and an LD50 is not available.
Justification for classification or non-classification
Sodium sulfide (Na2(Sx)) has been classified as Acute Tox. 3 based on the available information for oral acute toxicity and Acute Tox. 3 based on the available information for dermal acute toxicity. There is no data available for acute inhalation toxicity therefore the substance is not classified.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.