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EC number: 428-710-1 | CAS number: 207574-76-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
- Endpoint:
- basic toxicokinetics, other
- Type of information:
- other: Summary of available data
- Adequacy of study:
- key study
- Reliability:
- other: Expert statement
- Objective of study:
- other: Assessment of toxicokinetic behaviour
- Qualifier:
- according to guideline
- Guideline:
- other: Expert statement
- Principles of method if other than guideline:
- Assessment of toxicokinetic behaviour
- Conclusions:
- Interpretation of results: No toxicologically relevant observations were made in any study performed
The substance is toxicologically not relevant. It is not classified according to Regulation (EC) 1272/2008. In any toxicological study performed there is no concern raised. - Executive summary:
No specific study was performed on the absorption, distribution, metabolism and/or excretion (ADME) of WS400572. Predictions on toxicokinetics were based on physical-chemical properties and results of toxicological studies.
The UVCB substance consists of condensation products of m-phenylenebis(methylamine) with condensation products of 4-methyl-m-phenylene diisocyanate with alcohols, C10-14 (even numbered). The molecular weights of the condensation products range from 801 Da to 913 Da. Water solubility is very low, < 0.1 mg/l. The water/octanol partition coefficient was calculated to amount to log Pow > 10. The vapour pressure was calculated resulting in a value of < 10-23Pa.
The physico-chemical and toxicological information on the substance has been used to assess its toxicokinetic behaviour according to the ECHA “Guidance on information requirements and chemical safety assessment Chapter R.7c: Endpoint specific guidance”.
The UVCB substance contains various molecules with alkyl chains of different length. The average molecular diameters have been determined using the Chem3D Pro software, as specified in the TGD on data requirements and chemical safety assessment, appendix R.11-1 annex 2. Average molecular diameters were calculated for molecules containing two C10 (component I), two C12 (component II), and two C14 alkyl chains (component III); results are are summarised in the following table.
Component
Molecular formula
Molecular weight [Da]
Average molecular diameter [nm]
Component I
C46H68N6O6
801
3.75
Component II
C50H76N6O6
857
3.66
Component III
C54H84N6O6
913
4.33
Dermal absorption
The low water solubility and high lipophilicity (log Pow > 10) together with the high molecular weight of the constituents of WS400572 limit absorption across the skin. In animal tests, dermal or eye irritation as well as a skin sensitising potential were not observed.
Oral absorption
The low water solubility and high lipophilicity (log Pow > 10) together with the high molecular weight of the constituents of WS400572 limit absorption in the digestive tract. In tests for acute oral toxicity and toxicity after repeated oral dosing, no effects were observed in rats receiving once 5000 mg/kg bodyweight or repeatedly 1000 mg/kg bodyweight/day, respectively.
Respiratory absorption
WS400572 is solid and has a very low vapour pressure. It decomposes before boiling. Accordingly, inhalation is an unlikely route of human exposure. In addition, the substance is not used as such but always is formulated in solvents thus excluding exposure to particles.
Distribution, metabolism, and excretion
There is no information available on distribution, metabolism, and excretion of WS400572 in the available studies.
Based on the physical-chemical properties bioavailability of the components of WS400572 is very restricted. Also bioaccumulation is rather unlikely because the different components of the UVCB substance have high molecular weights (> 800 Da), very high octanol/water partition coefficient (log Pow > 10), and average molecular diameters above 1.7 nm. These properties indicate extremely low transport across biological membranes and thus low likeliness of absorption and bioaccumulation of the substance.
Reference
Description of key information
Key value for chemical safety assessment
Additional information
No specific study was performed on the absorption, distribution, metabolism and/or excretion (ADME) of WS400572. Predictions on toxicokinetics were based on physical-chemical properties and results of toxicological studies.
The UVCB substance consists of condensation products of m-phenylenebis(methylamine) with condensation products of 4-methyl-m-phenylene diisocyanate with alcohols, C10-14 (even numbered). The molecular weights of the condensation products range from 801 Da to 913 Da. Water solubility is very low, < 0.1 mg/l. The water/octanol partition coefficient was calculated to amount to log Pow > 10. The vapour pressure was calculated resulting in a value of < 10-23Pa.
The physico-chemical and toxicological information on the substance has been used to assess its toxicokinetic behaviour according to the ECHA “Guidance on information requirements and chemical safety assessment Chapter R.7c: Endpoint specific guidance”.
The UVCB substance contains various molecules with alkyl chains of different length. The average molecular diameters have been determined using the Chem3D Pro software, as specified in the TGD on data requirements and chemical safety assessment, appendix R.11-1 annex 2. Average molecular diameters were calculated for molecules containing two C10 (component I), two C12 (component II), and two C14 alkyl chains (component III); results are are summarised in the following table.
Component |
Molecular formula |
Molecular weight [Da] |
Average molecular diameter [nm] |
Component I |
C46H68N6O6 |
801 |
3.75 |
Component II |
C50H76N6O6 |
857 |
3.66 |
Component III |
C54H84N6O6 |
913 |
4.33 |
Dermal absorption
The low water solubility and high lipophilicity (log Pow > 10) together with the high molecular weight of the constituents of WS400572 limit absorption across the skin. In animal tests, dermal or eye irritation as well as a skin sensitising potential were not observed.
Oral absorption
The low water solubility and high lipophilicity (log Pow > 10) together with the high molecular weight of the constituents of WS400572 limit absorption in the digestive tract. In tests for acute oral toxicity and toxicity after repeated oral dosing, no effects were observed in rats receiving once 5000 mg/kg bodyweight or repeatedly 1000 mg/kg bodyweight/day, respectively.
Respiratory absorption
WS400572 is solid and has a very low vapour pressure. It decomposes before boiling. Accordingly, inhalation is an unlikely route of human exposure. In addition, the substance is not used as such but always is formulated in solvents thus excluding exposure to particles.
Distribution, metabolism, and excretion
There is no information available on distribution, metabolism, and excretion of WS400572 in the available studies.
Based on the physical-chemical properties bioavailability of the components of WS400572 is very restricted. Also bioaccumulation is rather unlikely because the different components of the UVCB substance have high molecular weights (> 800 Da), very high octanol/water partition coefficient (log Pow > 10), and average molecular diameters above 1.7 nm. These properties indicate extremely low transport across biological membranes and thus low likeliness of absorption and bioaccumulation of the substance.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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