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EC number: 269-054-2 | CAS number: 68186-92-5 This substance is identified in the Colour Index by Colour Index Constitution Number, C.I. 77896.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Additional information
In a GLP compliant study performed with C.I. Pigment Yellow 53 (CAS no.8007-18-9) as an analogous substance which shares the property of very low water solubility, according to OECD guideline 422, CD rats were administered orally 250, 500 or 1000 mg/kg bw/day for 46 d (males) or 41-45 d (females; MHLW 2002). The substance did not cause any significant effect on fertility in both P and F1 animals.
In a subchronic study performed with C.I. Pigment Yellow 53 (CAS no.8007-18-9) similar to OECD guideline 408, male and female Wistar rats were treated with 0.45, 4.5, 45 and 450 mg/kg bw/day for 90 d (Bomhard et al. 1982). No substance related effects on reproduction organs were found.
Additionally, there are no indications for bioavailability since the substance showed no bioavailability after oral and inhalative exposure. Additionally, no leaching of metal ions was detected in a leaching study (see water solubility section). No hazard is expected for the dermal exposure pathway. Therefore, additional studies for reproduction and developmental toxicity are not considered necessary.
Short description of key information:
The assessment for Chrome tungsten titanium buff rutile (CAS-no. 68186-92-5; C.I. Pigment Yellow 163) is based on a read-across from the chemically closely related rutile pigment C.I. Pigment Yellow 53 (CAS no.8007-18-9)
oral
rat, 46/41-45 d (m/f): NOAEL P, F1 >= 1000mg/kg bw/ day (MHLW 2002)
rat, 90 d: NOAEL P >= 450 mg/kg bw/ day (only reproductive organs; Bomhard et al. 1982)
Assessment: not bioavailable
Effects on developmental toxicity
Description of key information
oral
rat, 46/41-45 d (m/f): NOAEL maternal, teratogenicity >= 1000mg/kg bw/ day (MHLW 2002)
Assessment: not bioavailable
Additional information
Developmental toxicity
In a GLP compliant study performed according to OECD guideline 422, CD rats were administered orally 250, 500 or 1000 mg/kg bw/ day for 46 d (males) or 41-45 d (females; MHLW 2002). The substance did not cause any significant maternal or teratogenic effect.
Additionally, there are no indications for bioavailability since the substance showed no bioavailability after oral and inhalative exposure. Additionally, no leaching of metal ions was detected in a leaching study (see water solubility section). No hazard is expected for the dermal exposure pathwayt. Therefore, additional studies for reproduction and developmental toxicity are not considered necessary.
Justification for classification or non-classification
No indications were given for a toxic potential on reproduction or development. Endpoint is not relevant for non-bioavailable substances.
Additional information
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