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Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Remarks:
Well documented report, details missing

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1979
Report date:
1979

Materials and methods

Principles of method if other than guideline:
The test substance (ca. 0.5 g of the 80% suspension in water) was applied to a 2.5 x 2.5 cm application site of white Vienna rabbits for 3 min under occlusive conditions. The skin was left intact. Animals were observed for 8 days and skin changes were observed on working days. Findings were recorded after 24, 48 hours and at the end of the observation period. Findings were graded as described in OECD test guideline 404.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Sodium methanolate
EC Number:
204-699-5
EC Name:
Sodium methanolate
Cas Number:
124-41-4
Molecular formula:
CH4O.Na
IUPAC Name:
sodium methanolate

Test animals

Species:
rabbit
Strain:
Vienna White
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: Gaukler
- Weight at study initiation: 2.91 and 3.0 kg

Test system

Type of coverage:
occlusive
Preparation of test site:
shaved
Vehicle:
water
Controls:
other: untreated skin of the same animals
Amount / concentration applied:
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): ca. 0.5 g
- Concentration (if solution): 80%
Duration of treatment / exposure:
3 minutes
Observation period:
8 days
Number of animals:
2
Details on study design:
no information given

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
other: 1 animal of 2
Time point:
24 h
Score:
2
Max. score:
4
Reversibility:
not reversible
Remarks on result:
other:
Remarks:
extended patchy necrosis (not specified if animal 1 or 2), which led to full thickness necrosis of the skin (day 8)
Irritation parameter:
erythema score
Basis:
other: 1 animal of 2
Time point:
24 h
Score:
2
Max. score:
4
Reversibility:
not reversible
Remarks on result:
other:
Remarks:
patchy necrosis (not specified if animal 1 or 2), which led to full thickness necrosis of the skin (day 8)
Irritation parameter:
edema score
Basis:
other: 1 animal of 2
Time point:
24 h
Score:
2
Max. score:
4
Reversibility:
not fully reversible within: 8 days
Remarks on result:
other:
Remarks:
extended in 1 animal (not specified if animal 1 or 2)
Irritation parameter:
edema score
Basis:
other: 1 animal of 2
Time point:
24 h
Score:
2
Max. score:
4
Reversibility:
not fully reversible within: 8 day
Remarks on result:
other:
Remarks:
extended in 1 animal (not specified if animal 1 or 2)
Irritation parameter:
erythema score
Basis:
other: 1 animal of 2
Time point:
48 h
Score:
3
Max. score:
4
Reversibility:
not reversible
Remarks on result:
other: extended patchy necrosis (not specified if animal 1 or 2), which led to full thickness necrosis of the skin (day 8)
Irritation parameter:
erythema score
Basis:
other: 1 animal of 2
Time point:
48 h
Score:
4
Max. score:
4
Reversibility:
not reversible
Remarks on result:
other: very severe necrosis (parchement-like; not specified if animal 1 or 2), which led to full thickness necrosis of the skin (day 8).
Irritation parameter:
edema score
Basis:
animal: 1 animal of 2
Time point:
48 h
Score:
2
Max. score:
4
Reversibility:
not fully reversible within: 8 days
Remarks on result:
other: extended in 1 animal (not specified if animal 1 or 2)
Irritation parameter:
edema score
Basis:
other: 1 animal of 2
Time point:
48 h
Score:
2
Max. score:
4
Reversibility:
not fully reversible within: 8 days
Remarks on result:
other: extended in 1 animal (not specified if animal 1 or 2)
Irritation parameter:
erythema score
Basis:
mean
Time point:
72 h
Remarks on result:
not determinable
Remarks:
score not provided due to sever necrosis
Irritation parameter:
edema score
Basis:
mean
Time point:
72 h
Remarks on result:
not determinable
Remarks:
score not provided due to severe necrosis
Irritant / corrosive response data:
- 3 min: Erythema: 2 (2/2 animals), Edema 0 (2/2 animals)
- 8 days: Erythema: 4 (Necrosis, leather-like, 2/2 animals), Edema: 1 (2/2 animals)

Applicant's summary and conclusion

Interpretation of results:
Category 1A (corrosive) based on GHS criteria
Conclusions:
The test material was found to be corrosive to rabbit skin.