Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 205-489-6 | CAS number: 141-57-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 1994-11-30 to 1994-12-02
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- The study was conducted according to an appropriate OECD test guideline, and in compliance with GLP, and was considered to be reliability 1 (reliable without restrictions). Read across to the registered substance is considered scientifically justified; the read across is considered to be reliability 2.
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Details on sampling:
- Test substance concentration determined in the stock solution used to prepare the test media.
Test substance concentration was determined in all treatments at the start and end of the test. - Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION
- Method: A 1000 mg/L stock solution was prepared by mixing for 18 hours followed by filtration. The other treatments were prepared by dilution of the stock solution. The measured DOC concentration in the stock solution was 398 mg/L which was equivalent to 907 mg/l of the test substance.
- Controls: Dilution water - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Daphnia magna
- Strain: Clone 5
- Source: Stock culture
- Age at study initiation (mean and range, SD): <24 h
- Method of breeding: Parthenogenetic reproduction
- Feeding during test: None
ACCLIMATION
- Acclimation conditions (same as test or not): yes
- Type and amount of food: sufficient to be consumed each day leaving no residue
- Feeding frequency: daily - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Hardness:
- The sum of the Ca2+ and Mg2+ ions was 2.5 mmol
- Test temperature:
- 20 +/-1ºC
- pH:
- 7.8
- Dissolved oxygen:
- 8.2 - 8.4 mg/L
- Salinity:
- not applicable
- Nominal and measured concentrations:
- Nominal: 0(Control), 54, 91, 163, 272, 481 and 816 mg/L
Measured concentration in stock solution used to prepare test media: 907 mg/L
Measured concentration in treatments at the start of the test: 58, 92, 190, 270, 488 and 814 mg/L
Measured concentration in treatments at the end of the test: 57, 90, 166, 266, 475 and 785 mg/L
Concentrations used as the basis for assessing effects: Control, 54, 91, 163, 272, 481 and 816 mg/L - Details on test conditions:
- TEST SYSTEM
- Test vessel:
- Type: open
- Material, size, headspace, fill volume: glass cylinder containing 10 mL of test medium
- Aeration: none
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Elendt M4 medium
- Intervals of water quality measurement: end of test
OTHER TEST CONDITIONS
- Photoperiod: Dark
EFFECT PARAMETERS MEASURED: Immobilization after 24 and 48 h exposure
TEST CONCENTRATIONS
- Spacing factor for test concentrations: 1.7 - Reference substance (positive control):
- yes
- Remarks:
- Potassium dichromate
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 816 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks:
- but exposure is to hydrolysis products
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 816 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks:
- but exposure is to hydrolysis products
- Basis for effect:
- mobility
- Details on results:
- - Mortality of control: 0
- Other adverse effects control: none reported - Results with reference substance (positive control):
- 48-h EC50: >1.0, <2.0 mg/l
- Reported statistics and error estimates:
- The were no toxic effects observed in the highest test concentrations and therefore statistical analysis of the results was not carried out.
- Validity criteria fulfilled:
- yes
- Conclusions:
- A 48-h EC50 value of >816 mg/L and NOEC of ≥816 mg/L have been determined for the effects of the test substance on mobility of Daphnia magna based on nominal concentrations of the substance. It is likely that the test organisms were exposed to the hydrolysis products of the substance.
Reference
Table 1. Test results
Nominal test concentration (mg/L) | Mean percentage immobilisation after 24 hours | Mean percentage immobilisation after 48 hours |
0 (Control) | 0 | 0 |
54 | 0 | 0 |
91 | 0 | 0 |
163 | 5 | 5 |
272 | 5 | 5 |
481 | 0 | 0 |
816 | 0 | 0 |
Description of key information
Short-term toxicity to invertebrates: 48 hour EC50 >816 mg/l (mean measured DOC) (highest concentration tested) (EU Method C.2 (Acute Toxicity for Daphnia)), read-across from an analogous/structurally related substance, trimethoxy(propyl)silane (CAS 1067-25-0). The observations in this study are attributed to the exposure of test organisms to the hydrolysis products in the test system.
Key value for chemical safety assessment
Additional information
There are no reliable short-term invertebrate toxicity data available for trichloro(propyl)silane (CAS 141-57-1), therefore good quality data for an appropriate structural analogue, trimethoxy(propyl)silane (CAS 1067-25-0), have been read across. Both substances share the same silanol hydrolysis product, propylsilanetriol. The other hydrolysis products are hydrochloric acid and methanol, respectively. In the test with trimethoxy(propyl)silane (CAS 1067-25-0), the observations are attributed to the exposure of test organisms to propylsilanetriol in the test system. There is no basis to expect that methanol significantly influenced the results of the test. The toxicity of methanol is discussed further in the ecotoxicological information overview endpoint summary (additional information).
A 48-hour EC50 value of >816 mg/l (mean measured DOC) (highest concentration tested) have been determined for the effects of trimethoxy(propyl)silane (CAS 1067-25-0) on mobility of Daphnia magna. In view of the test media preparation method and exposure regime it is likely that the test organisms were exposed predominantly to the hydrolysis products of the tested substance. The test concentrations are reported in terms of DOC and are therefore not further adjusted in terms of concentration of parent corrected to concentration of silanol.
Above a concentration of approximately 1000 mg/l, dimeric / oligomeric, cyclic or cross-linked condensation products could potentially form over time in the aqueous test media. No evidence of undissolved material (parent substance or precipitated products) is indicated in the study report for this test.
Refer to the discussion in the Section 6 endpoint summary (Section 7.0 of CSR) for further discussion of the approach to chemical safety assessment for this registration substance, and justification for read-across used.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.