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EC number: 206-743-9 | CAS number: 372-09-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
SKIN IRRITATION
Combining the results of a full-scale test and of a screening test, Cyanoacetic acid is severely irritating to the skin based on induction of necrosis after a 3-minute exposure (OECD GHS Category 1B (corrosive)).
EYE IRRITATION
Cyanoacetic acid is severely irritating to the eye based on the severity of corneal opacity (OECD GHS Category 1 (irreversible effects on the eye / serious damage to the eye)).
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
SKIN IRRITATION
In a primary dermal irritation study (BASF 1980), young adult Vienna White rabbits (2 males and 4 females) were dermally exposed to approximately 0.5 g of Cyanoacetic acid (purity not given) in water (area of the flanks sized approximately 2.5 cm x 2.5 cm; application to both intact and abraded skin). Animals then were observed for 3 days. Irritation was scored by the method of Draize.
Severe erythema and well-defined to severe edema as well as necrosis was observed in each animal at each reading. There were not significant differences between intact and abraded skin sites. The study was discontinued at 72 h after beginning of application due to severe irritation effects. Necrosis was confirmed by pathology. Primary irritation index was 6.9 (possible maximum: 8.0).
In a screening study (4 rabbits, application of Cyanoacetic acid (purity not given) in water for 3 minutes and 1 hour), well-defined erythema, slight edema and necrosis was observed following application for 3 minutes. Application for 1 hour caused severe irritation including necrosis.
Combining the results of these two tests, Cyanoacetic acid is severely irritating to the skin based on induction of necrosis after a 3-minute exposure (OECD GHS Category 1B (corrosive)).
EYE IRRITATION
In a primary eye irritation study (BASF 1980), 62 mg (equivalent to 0.1 ml bulk volume) of unchanged Cyanoacetic acid (purity not given) was instilled into the conjunctival sac of one eye of young adult Vienna White rabbits (5 males and 1 female) without rinsing. Animals then were observed for 8 days. Irritation was scored by the method of Draize.
Strong corneal opacity (Draize score 3; affecting >3/4 of the cornea surface), strong conjunctival swelling, strong lacrimation, necrosis at the rim of the eyelid, and suppuration was noted in any animal at any reading. Scores for conjunctival redness and iris could not be determined due to suppuration and/or coloration with the test substance. Primary irritation index was >=71 (possible maximum: 110).
In this study, Cyanoacetic acid is severely irritating to the eye based on the severity of corneal opacity (OECD GHS Category 1 (irreversible effects on the eye / serious damage to the eye)).
Effects on skin irritation/corrosion: corrosive
Effects on eye irritation: corrosive
Justification for classification or non-classification
Based on the induction of necrosis after a 3-minute exposure, Cyanoacetic acid has to be classified as “corrosive” according to the Directive 67/548/EC. According to the GHS criteria, Cyanoacetic acid has to be classified as follows: Category 1B (corrosive).
Based on the severity of the induced corneal opacity, Cyanoacetic acid has to be classified as “risk of serious damage to the eye” according to the Directive 67/548/EC. According to the GHS criteria, Cyanoacetic acid has to be classified as follows: Category 1(irreversible effects on the eye / serious damage to the eye).
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