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Diss Factsheets
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EC number: 251-646-7 | CAS number: 33703-08-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: GLP comparable to guideline study
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test)
- Principles of method if other than guideline:
- aerobic guideline: EEC Directive 79-831 Annex V, Part C, Manometric Respirometry Year: Bruessel 1984
Remark: Method is comparable to OECD guideline 301 F and ISO 9408 - GLP compliance:
- yes
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Details on inoculum:
- - Activated sludge from laboratory waste water plant Oppau, Ludwigshafen, Germany
- Concentration of dry substance in the test = 30 mg/L
- 10 mL aliquot of sludge added per test - Duration of test (contact time):
- 28 d
- Initial conc.:
- 200 mg/L
- Based on:
- test mat.
- Initial conc.:
- 50 mg/L
- Based on:
- test mat.
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- - stock solution: 759 mg/g DOC
- concentration of test substance: 50, 100, 200 mg/l - Reference substance:
- aniline
- Key result
- Parameter:
- % degradation (O2 consumption)
- Value:
- > 90
- Sampling time:
- 28 d
- Details on results:
- - lag phase 1 day
- degradation phase 4 days
- biodegradation degree after 28 days: >90%
- the test substance was readily biodegradable - Results with reference substance:
- - Reference substance: aniline
- degradation phase 2 days
- DOC elimination 96 %
- BOD/ThOD = 75%
- lag phase 4 days - Validity criteria fulfilled:
- not specified
- Interpretation of results:
- readily biodegradable
- Conclusions:
- The test substance reached a biodegradation of > 90% in 28 days. Therefore, the test substance is readily biodegradable according to OECD criteria.
Reference
Description of key information
Readily biodegradable (according to OECD criteria): > 90% in 28 days (similar to OECD 301F)
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
Additional information
One study investigating the biodegradability of Diisononyl adipate is available. The study was performed under GLP conditions in a manometric respirometry test according to EU method C.4-D (equivalent to OECD 301F) (BASF 1985). Non-adapted domestic activated sludge was used as inoculum. After 28 days a biodegradation of > 90% was observed. Thus, DINA is readily biodegradable according to OECD criteria.
Based on the distribution of the UVCB primary nonyl alcohol that is used for the synthesis of DINA, the most common isomers of DINA have an C8- (~ 50%) or C7- (~ 40%) main chain. For this reason, the biodegradability of five representative structures of DINA with varyiing main chain length (linear, C7,C8) was assessed by QSAR calculations with the well established model Catabol 310B v.02.07. Isomer 1 (C8), isomer 2 (C8), isomer 4 (C7) and isomer 5 (C9) did completely fall in the applicability domain of the model. Isomer 3 (C7) was completely in the parameter domain and the metabolic domain, but 7.14% of the structural fragments were not present in the training chemicals set. Although isomer 3 was slightly out of the structural domain, the prediction is in line with the calculations for the other isomers and can yet be considered reliable.
For all isomers a biodegradation of > 70% after 28d was determined supporting the results of the available experimental study according to OECD 301F (BASF, 1985). Consequently diisononyl adipate can be considered readily biodegradable.
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