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EC number: 236-921-1 | CAS number: 13548-38-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- weight of evidence
- Study period:
- 1967
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: CrCl3, a structural analogue of chromic nitrate, can be used for read-across.
Data source
Reference
- Reference Type:
- publication
- Title:
- Sensitization of guinea pigs to chromium salts.
- Author:
- Gross PR, Katz SA, Samitz MH (1968)
- Year:
- 1 968
- Bibliographic source:
- Journal of investigative Dermatology, 50:424–427.
- Report date:
- 1967
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 406 (Skin Sensitisation)
- Deviations:
- not specified
- GLP compliance:
- no
- Type of study:
- guinea pig maximisation test
Test material
- Reference substance name:
- chromium chloride
- IUPAC Name:
- chromium chloride
- Reference substance name:
- Chromium trichloride
- EC Number:
- 233-038-3
- EC Name:
- Chromium trichloride
- Cas Number:
- 10025-73-7
- Test material form:
- not specified
- Details on test material:
- N/A
Constituent 1
Constituent 2
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals and environmental conditions:
- Albino guinea pigs weighing 300 and 500 Gm.
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- other: subcutaneous
- Vehicle:
- no data
- Concentration / amount:
- the sensitizing injections contained 0.5 cc of Freund's complete adjuvant with 0.5 cc of 3.4 × 10-2 M CrCl3. The test dose was 0.1 cc of 4.2 × 10-4 M CrC13 in physiologic saline intradermally
Challengeopen allclose all
- Route:
- intradermal
- Vehicle:
- no data
- Concentration / amount:
- the sensitizing injections contained 0.5 cc of Freund's complete adjuvant with 0.5 cc of 3.4 × 10-2 M CrCl3. The test dose was 0.1 cc of 4.2 × 10-4 M CrC13 in physiologic saline intradermally
- No. of animals per dose:
- 13: chromium chloride;
30: control group - Details on study design:
- Thirteen guinea-pigs were given chromium trichloride hexahydrate by three subcutaneous injections in the nape 1 week apart. The sensitizing injections contained 0.5 ml of FCA with 0.5 ml of 3.4 × 10−2mol chromium chloride hexahydrate/l. Three weeks later, the animals were tested with an intradermal injection into clipped or epilated skin. The eliciting dose was 0.1 ml of 4.2 × 10−4 mol chromium chloride hexahydrate/l.
- Challenge controls:
- N/A
- Positive control substance(s):
- not specified
Results and discussion
- Positive control results:
- N/A
In vivo (non-LLNA)
Results
- Reading:
- 1st reading
- Hours after challenge:
- 48
- Group:
- test chemical
- Dose level:
- 4.2 × 10−4 mol
- No. with + reactions:
- 10
- Total no. in group:
- 13
- Clinical observations:
- developed positive reactions (at least +) ; of these, four were read as (+2). None developed (+3) or (+4) reactions.
- Remarks on result:
- other: see Remark
- Remarks:
- Reading: 1st reading. . Hours after challenge: 48.0. Group: test group. Dose level: 4.2 × 10−4 mol . No with. + reactions: 10.0. Total no. in groups: 13.0. Clinical observations: developed positive reactions (at least +) ; of these, four were read as (+2). None developed (+3) or (+4) reactions..
Applicant's summary and conclusion
- Interpretation of results:
- sensitising
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Based on the results, chromium trichloride hexahydrate is a sensitizer to guinea pigs' skin at the 3.4 × 10−2 M under the conditions of this report.
- Executive summary:
Thirteen guinea-pigs were given chromium trichloride hexahydrate by three subcutaneous injections in the nape 1 week apart. The sensitizing injections contained 0.5 ml of FCA with 0.5 ml of 3.4 × 10−2mol chromium chloride hexahydrate/l. Three weeks later, the animals were tested with an intradermal injection into clipped or epilated skin. The eliciting dose was 0.1 ml of 4.2 × 10-4 mol chromium chloride hexahydrate/l. After 48 h, this produced moderate positive responses in 10 of the 13 animals, whereas the control animals (injected only with FCA) showed no reactions. Of the 10 guinea-pigs sensitized to chromium chloride, 3 elicited weaker cross-reactions after intradermal injection of chromium nitrate (9.6 × 10-4 mol/l).
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