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Diss Factsheets
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EC number: 205-792-3 | CAS number: 151-50-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / bone marrow chromosome aberration
- Remarks:
- Type of genotoxicity: DNA damage and/or repair
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: This study precedes the establishment of, but is similar to, OECD Guideline protocol for the in vivo Micronucleus assay.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EPA OPPTS 870.5385 (In Vivo Mammalian Cytogenetics Tests: Bone Marrow Chromosomal Analysis)
- Principles of method if other than guideline:
- Other: U.S. EPA Health Effects guidelines
EPA Report 560/5-83-001 - GLP compliance:
- yes
- Type of assay:
- other: cytogenetics chromosomes aberration assay
Test material
- Reference substance name:
- 2-hydroxy-2-methylpropionitrile
- EC Number:
- 200-909-4
- EC Name:
- 2-hydroxy-2-methylpropionitrile
- Cas Number:
- 75-86-5
- Molecular formula:
- C4H7NO
- IUPAC Name:
- 2-hydroxy-2-methylpropanenitrile
- Details on test material:
- IUCLID 4 Test Substance: as prescribed by 1.1-1.4
98.5% Acetone cyanohydrin. Certificate of Analysis
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
Administration / exposure
- Route of administration:
- oral: gavage
- Details on exposure:
- approximates the LD 50 of 17 mg/kg bw, from previous studies with rats.
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0, 1.5 & 15mg/kg
Basis:
nominal conc.
- No. of animals per sex per dose:
- 6
- Control animals:
- yes, concurrent vehicle
Examinations
- Statistics:
- yes
Results and discussion
Test results
- Sex:
- male/female
- Genotoxicity:
- negative
- Toxicity:
- no effects
- Vehicle controls validity:
- valid
- Positive controls validity:
- valid
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): negative
Six animals per sex per group were administered ACH at dosages of 1.5 & 15 mg/kg bw, and were sacrificed at 6, 12, 24 and 48 hours after dosing. Body weights recorded before dosing and at 24 and 48 hr time points. Bone marrow cells were processed according to the modified techniques described by Evans (1977).
Animals were observed for general appearance, behaviour, toxic and pharmacological effects twice daily or prior to sacrifice. The concentrations tested were approximately to the established LD50 of acetone cyanohydrin in the rat, 17 mg/kg bw, from a previous study to approximate the oral LD50. No gross signs of toxicity were apparent in this study. Acetone cyanohydrin demonstrates a steep dose response curve for acute toxicity with little or no signs of toxicity at sub-lethal doses. There was no statistically significant increase in the frequency of chromosomal aberrations compared withcontrols at any dose level. Acetone cyanohydrin is considered non-clastogenic and non-genotoxic.
Hydrogen cyanide (Index No.006-006-00-X) and salts of hydrogen cyanides (Index No.006-007-00-5) are both listed in Annex VI, Table 3.1 of Regulation (EC) No. 1272/2008, entry 006-007-00-5, and are restricted in comparable ways taking into account physical characteristics. Thus, the assignment of potassium cyanide and sodium cyanide to a chemical category does not result in a less protective regulatory status.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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