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Diss Factsheets

Physical & Chemical properties

Water solubility

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2010-01-19 to 2010-01-21
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Remarks:
OECD 105, GLP.
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Version / remarks:
(1995)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Version / remarks:
Directive 92/69/EC (1992)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
column elution method
Key result
Water solubility:
5.44 mg/L
Temp.:
20 °C
pH:
6.4
Remarks on result:
other: The limit of quantification of the analytical method was fixed at 2 mg/L.
Water solubility:
6.35 mg/L
Temp.:
30 °C
pH:
6.4
Remarks on result:
other: The limit of quantification of the analytical method was fixed at 2 mg/L.
Conclusions:
Interpretation of result: slightly soluble (0.1-100 mg/L)
In a valid guideline study (OECD 105, with GLP) using the columns elution method the solubility of IBOMA in water was determined to be 5.44 mg/L at 20 °C and 6.35 mg/L at 30 °C. The pH value of all test solutions was 6.4. So the test substance is considered to be slightly soluable. No temperature dependence of the water solubility was observed.
Executive summary:

In a valid guideline study (OECD 105, with GLP) using the columns elution method the solubility of IBOMA in water was determined to be 5.44 mg/L at 20 °C and 6.35 mg/L at 30 °C. The pH value of all test solutions was 6.4.

Analyses were performed by HPLC-UV on a reversed-phase column (C 18) using external standards. The pH values of the

samples were measured with special indicator sticks. All samples were checked to ensure that no colloidal material was present by measuring the Tyndall effect.

So the test substance is considered to be slightly soluable. No temperature dependence of the water solubility was observed.

NOTE: Any of data in this dataset are disseminated by the European Union on a right-to-know basis and this is not a publication in the same sense as a book or an article in a journal. The right of ownership in any part of this information is reserved by the data owner(s). The use of this information for any other, e.g. commercial purpose is strictly reserved to the data owners and those persons or legal entities having paid the respective access fee for the intended purpose.

Description of key information

5.44 mg/L at 20°C, Lange 2009, OECD 105 (column elution method), GLP

Key value for chemical safety assessment

Water solubility:
5.44 mg/L
at the temperature of:
20 °C

Additional information

The key study (Lange, 2009) reports a value of 5.44 mg/L at 20°C. This value is also consistent with a preliminary study for water solubility (Evonik Röhm GmbH, 1988) and a valid calculated value for IBOMA using EpiWin version 4.00.