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EC number: 247-955-1 | CAS number: 26748-41-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1976
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- , number of animals per sex and dose, dose levels examined, no necropsy of the survivers
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- tert-butyl peroxyneodecanoate
- EC Number:
- 247-955-1
- EC Name:
- tert-butyl peroxyneodecanoate
- Cas Number:
- 26748-41-4
- Molecular formula:
- C14H28O3
- IUPAC Name:
- Reaction products of neodecanoic acid (or neodecanoyl chloride derived from neodecanoic acid) and tert-butyl hydroperoxide
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 2374 to 2776 gr.
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- The hair was clipped from the back of each rabbit. The skin was abraded for 1/2 of the rabbits in each group. The test material was applied, as received, to the backs in appropriate doses. the site of application was covered with gause bandaging and occluded with saran wrap.
- Duration of exposure:
- 24 hours
- Doses:
- 1000, 2000, 4000, 8000 mg/ kg bw
- No. of animals per sex per dose:
- 2 animals of one sex were used for each dose level
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: daily
- Necropsy of survivors performed: no
- Other examinations performed: clinical signs, body weight, organ weights
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- 8 000 mg/kg bw
- Based on:
- test mat.
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 8 000 mg/kg bw
- Based on:
- test mat.
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 6 000 mg/kg bw
- Based on:
- act. ingr.
- Mortality:
- No mortality was observed
- Clinical signs:
- other: Not indicated
- Gross pathology:
- Not performed as all animals survived
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- A LD50 value of > 8000 mg/kg bw was determined in the study for the test substance 75 % t-butyl peroxyneodecacnoate in solvent. A LD50 value of > 6000 mg/kg bw was calculated for 100 % t-butyl peroxyneodecanoate.
- Executive summary:
The test substance 75 % t-butyl peroxyneodecanoate in mineral spirits was examined for its acute dermal toxicity, similar to an OECD no. 402 study guideline. Eight New Zealand white rabbits were equally divided to sex and to 4 dosage groups of 1000, 2000, 4000, and 8000 mg/kg bw. The hair was clipped from the back of each rabbit, the test substance was applied for 24 hours, as received to the backs in appropriate doses and the application site was covered with gauze bandaging and occluded with saran wrap.
After observation time of 14 days no mortality was observed and all rabbits exhibited body weight gains or maintained their body weight during the 14 day observation period. Thus, the deduced LD0 and LD50 values and are 8000 mg/kg bw and > 8000 mg/kg bw respectively. A LD50 value of > 6000 mg/ kg bw is calculated for 100 % t-butyl peroxyneodecanoate.
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