Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-846-2 | CAS number: 75-18-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Adequacy of study:
- other information
- Study period:
- data not available
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Fatality due to inhalation of dimethyl sulfide in a confined space: a case report and animal experiments
- Author:
- Terazawa K, Mizukami K, Wu B and Takatori T
- Year:
- 1 991
- Bibliographic source:
- Int. J. Legal. Med., 104(3), 141-4
Materials and methods
- Study type:
- poisoning incident
Test guideline
- Qualifier:
- no guideline required
Test material
- Reference substance name:
- Dimethyl sulphide
- EC Number:
- 200-846-2
- EC Name:
- Dimethyl sulphide
- Cas Number:
- 75-18-3
- Molecular formula:
- C2H6S
- IUPAC Name:
- (methylsulfanyl)methane
Constituent 1
Method
- Type of population:
- occupational
- Subjects:
- - Number of subjects exposed: 1
- Sex: male
- Age: 25 years old
- Race: data not available
- Demographic information: data not available
- Known diseases: data not available - Ethical approval:
- not applicable
- Route of exposure:
- inhalation
- Reason of exposure:
- accidental
- Exposure assessment:
- not specified
- Examinations:
- DMS was quantified in tissues by GC method equipped with a flame photometric detector.
Results and discussion
- Clinical signs:
- In a paper manufacturing plant in Ebetsu, Hokkaido, Japan, a fatal accident occurred in a round storage tank (5m in height, 4m in diameter). Two men entered the tank to clean the bottom, where they immediately collapsed and were retrieved. One was already dead and the other died 1.5 days later. It was suspected that toxic gases had entered the tank through a pipe from another tank and had accumulated at the bottom. Later, the atmosphere was sampled to determine the concentrations of toxic gases: hydrogen sulfide was not detected, methyl mercaptan was present in a concentration less than 10ppm, dimethyl sulfide (DMS) several ppm and dimethyl disulfide less than 1 ppm.
- Results of examinations:
- Autopsy:
The 25-year-old man was already dead when retrieved and an autopsy was performed 27 h after the accident. A disagreeable odour smelling of garlic was detected on the body surface and in the mouth. Lividity was tinted brown and petechial haemorrhages were seen in the conjunctivae. The cardiac blood also had a tint of brown and was fluid. The left lung weighed 600 g, the right 760g and both were rich in blood and oedematous. Other organs were also congested. Blood and organ samples were taken for toxicological analyses. Microscopically no abnormalities could be detected except for congestion in every organ. - Outcome of incidence:
- From the circumstances of the case it was thought that the death of victim had occurred over a very short period of time from poisoning by sulfur
compound gases and/or from asphyxia due to the hypoxic atmosphere by substituion of the gases. The pathological findings were consistent with the above causes of death, which have occurred immediately.
Any other information on results incl. tables
Measured concentration of DMS in tissues of the victim were as follow:
Tissue |
DMS (mg/g, wet weight) |
Lung |
0.11 |
Blood |
0.20 |
Heart muscle |
0.08 |
Brain |
0.23 |
Liver |
0.06 |
Spleen |
0.21 |
Kidney |
0.14 |
Muscle |
0.01 |
Adipose tissue |
0.04 |
Applicant's summary and conclusion
- Executive summary:
A man was found dead in a tank where gaseous dimethyl sulfide (DMS) was present. The concentrations of DMS in the blood and tissue samples were measured by gas chromatography. Mice were experimentally exposed to various concentrations (5%-55%) of gaseous DMS in a confined space and the course of death and DMS distribution in the bodies were observed to obtain diagnostic criteria for DMS poisoning. As a result it was considered that the cause of death of the victim was consistent with a combination of DMS poisoning and asphyxia due to a hypoxic atmosphere.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.