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EC number: 230-392-0 | CAS number: 7087-68-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- end 2004-01-16
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 004
- Report date:
- 2004
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- The temperature and relative humidity recorded in the animal room were somtetimes outside of the target ranges specified in the Study plan. The test item was not protected from light.
- GLP compliance:
- yes
Test material
- Reference substance name:
- Ethyldiisopropylamine
- EC Number:
- 230-392-0
- EC Name:
- Ethyldiisopropylamine
- Cas Number:
- 7087-68-5
- Molecular formula:
- C8H19N
- IUPAC Name:
- ethylbis(propan-2-yl)amine
- Details on test material:
- - Name of test material (as cited in study report): Ethyldiisopropylamine
- Physical state: liquid
- Analytical purity: 99.65%
- Purity test date: 2002-10-09
- Lot/batch No.: JT010101
- Expiration date of the lot/batch: June 2004
- Stability under test conditions: no data
- Storage condition of test material: in dark, protected from moisture and at temperature < 50°C
- Other: Atofina-La Chambre
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: CEVAG, Saint Mars d'Egrenne, France
- Age at study initiation: 2 to 4 month old
- Weight at study initiation: 3.1+/-0.1kg
- Housing: indidually in polystyrene cages (48.2x58x36.5cm)
- Diet (e.g. ad libitum): ad libitum 110 pellet diet (SAFE, Villemoisson, Epinay-sur-Orge, France)
- Water (e.g. ad libitum): ad libitum water filtered by a FG Miliipore membrane (0.22µ)
- Acclimation period:at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 18+/-3°C
- Humidity (%): 30-70%
- Air changes (per hr): approximately 12 cycles / hour
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: To: 2003-08-12
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- other: clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: auto-control
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5mL - Duration of treatment / exposure:
- 3 minutes and 4 hours
- Observation period:
- 1 hour, 24, 48, 78 hours after removal of the dressing then daily until D15.
- Number of animals:
- 3
- Details on study design:
- TEST SITE
- Area of exposure: no data
- Type of wrap if used: dry gauze pad held in contact by an adhesive hypoallergenic aerated semi occlusive dressing and a restraining bandage.
SCORING SYSTEM: according to the OECD N°404 Guideline scoring scale
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 1.7
- Max. score:
- 4
- Reversibility:
- fully reversible within: 11 days
- Remarks on result:
- other: 3min of exposure
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: 3-min exposure
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 1.7
- Max. score:
- 4
- Reversibility:
- fully reversible within: 11 days
- Remarks on result:
- other: 4-hour exposure
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 13 days
- Remarks on result:
- other: 4-hour exposure
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 13 days
- Remarks on result:
- other: 4-hour exposure
- Irritation parameter:
- edema score
- Basis:
- animal: #1, 2 and 3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: 4-hour exposure
- Irritant / corrosive response data:
- After a 3-minute exposure (one animal), a very slight or slight erythema (grade 1 or 2) was observed from day 1 up to day 14. Dryness of the skin was noted from day 6 up to the end of the observation period (day 15).
After a 4-hour exposure (three animals), a very slight or slight erythema (grade 1 or 2) was recorded in all animals from day 1 up to day 10 or 12. A slight oedema (grade 2) was noted in 1/3 animals on days 5 and 6. Dryness of the skin, sometimes together with crusts in 1/3 animals, was also observed in 2/3 animals between days 5 and 10 or between days 6 and 12.
Any other information on results incl. tables
3 min exposure |
1h |
24h |
48h |
72h |
D5 |
D6 |
D7 |
D8 |
D9 |
D10 |
D11 |
D12 |
D13 |
D14 |
D15 |
|
Erythema |
951 |
1 |
1 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
1 |
1 |
1 |
1 |
0 |
Oedema |
951 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
Other |
951 |
* |
* |
* |
* |
* |
S |
S |
S |
S |
S |
S |
S |
S |
S |
S |
* = none
S = dryness of the skin
4 h exposure |
1h |
24h |
48h |
72h |
D5 |
D6 |
D7 |
D8 |
D9 |
D10 |
D11 |
D12 |
D13 |
D14 |
D15 |
|
Erythema |
951 |
1 |
1 |
2 |
2 |
2 |
1 |
1 |
1 |
1 |
1 |
0 |
- |
- |
|
|
|
926 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
1 |
1 |
1 |
1 |
1 |
0 |
|
|
|
927 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
2 |
1 |
1 |
0 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Oedema |
951 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
- |
- |
|
|
|
926 |
0 |
0 |
0 |
0 |
2 |
2 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
|
|
927 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Other |
951 |
* |
* |
* |
* |
* |
* |
* |
* |
* |
* |
* |
- |
- |
|
|
|
926 |
* |
* |
* |
* |
S |
S |
S |
S |
S |
S |
* |
* |
* |
|
|
|
927 |
* |
* |
* |
* |
* |
S |
S |
S/A |
S/A |
S/A |
S |
S |
* |
|
|
* = none
S = dryness of the skin
A = crust
- = cutaneous examination performed
Applicant's summary and conclusion
- Interpretation of results:
- moderately irritating
- Remarks:
- Migrated information not classified according to CLP, R38 according to DSD Criteria used for interpretation of results: EU
- Conclusions:
- Mean scores over 24, 48 and 72 hours for each animal were 1.7, 2.0 and 2.0 for erythema and 0.0, 0.0 and 0.0 for oedema.
- Executive summary:
The dermal irritation of Ethyldiisopropylamine (EDIPA) was evaluated in male New Zealand White rabbits according to OECD N°404 Guideline.
0,5mL of EDIPA was applied during 4 hours in 3 rabbits and during 3 minutes in 1 rabbit on clipped area. The cutaneous reaction was observed one hour, 24, 48, 72 hours after removal of the dressing and then daily to day 15.
After a 3-minute exposure of 0.5mL of EDIPA (one animal), a very slight or slight erythema was observed from day 1 up to day 14. Dryness of the skin was noted from day 6 up to the end of the observation period (day 15). After a 4-hour exposure (three animals), a very slight or slight erythema was recorded in all animals from day 1 up to day 10 or 12. A slight oedema was noted in 1/3 animal on days 5 and 6. Dryness of the skin, sometimes together with crusts in 1/3 animal, was also observed in 2/3 animals between days 5 and 10 or between days 6 and 12.
Mean scores over 24, 48 and 72 hours for each animal were 1.7, 2.0 and 2.0 for erythema and 0.0, 0.0 and 0.0 for oedema.
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