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EC number: 205-999-9 | CAS number: 280-57-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study pre-dates GLPs Test material purity was not documented.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: Section 1500.41 - Federal Hazardous Substances A c t Regulations - 16 CFR - Po 124.
- Principles of method if other than guideline:
- Draize Test
A group of six albino rabbits was clipped over a wide area. One side of the animals' backs was abraded a t one site with a
lancet sufficiently deep to penetrate the stratum corneum but not enter the derma t o produce bleeding. The skin of the
other side was allowed to remain intact.
A 0.5 gm portion of material was applied to an abraded and an intact skin site on the same rabbit. Gauze patches were then
placed over the treated areas and an impervious material was wrapped snugly around the trunks of the animals to hold the
patches in place.
The wrapping was removed at the end of the twenty-four hour period and the treated areas were examined. Readings were
also made after seventy-two hours. The Draize method of scoring was employed. - GLP compliance:
- no
Test material
- Reference substance name:
- 1,4-diazabicyclooctane
- EC Number:
- 205-999-9
- EC Name:
- 1,4-diazabicyclooctane
- Cas Number:
- 280-57-9
- Molecular formula:
- C6H12N2
- IUPAC Name:
- 1,4-diazabicyclooctane
- Test material form:
- solid: crystalline
- Details on test material:
- IUCLID4 Test substance: as prescribed by 1.1 - 1.4Dabco lot # 80-D-8
Constituent 1
Test animals
- Species:
- rabbit
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: clipped+abradded
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- undiluted
- Duration of treatment / exposure:
- 24 hour(s)
- Observation period:
- 72 h
- Number of animals:
- 6
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: 24h and 72h
- Score:
- 2.92
- Reversibility:
- not specified
- Remarks on result:
- other: Study was done before OECD guidelines were established, hence there are no 48 h data available.
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Remarks:
- intact skin
- Time point:
- 24 h
- Score:
- 2
- Reversibility:
- not specified
- Remarks on result:
- other: erythema and eschar formation
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Remarks:
- intact skin
- Time point:
- 72 h
- Score:
- 3
- Reversibility:
- not specified
- Remarks on result:
- other: erythema and eschar formation
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Remarks:
- abraded skin
- Time point:
- 24 h
- Score:
- 2
- Reversibility:
- not specified
- Remarks on result:
- other: erythema and eschar formation
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Remarks:
- abraded skin
- Time point:
- 72 h
- Score:
- 3
- Reversibility:
- not specified
- Remarks on result:
- other: erythema and eschar formation
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Remarks:
- intact skin
- Time point:
- 24 h
- Score:
- 2
- Reversibility:
- not specified
- Remarks on result:
- other:
- Remarks:
- erythema and eschar formation
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Remarks:
- intact skin
- Time point:
- 72 h
- Score:
- 2
- Reversibility:
- not specified
- Remarks on result:
- other: erythema and eschar formation
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Remarks:
- abraded skin
- Time point:
- 24 h
- Score:
- 2
- Reversibility:
- not specified
- Remarks on result:
- other: erythema and eschar formation
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Remarks:
- abraded skin
- Time point:
- 72 h
- Score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- other: erythema and eschar formation
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Remarks:
- intact skin
- Time point:
- 24 h
- Score:
- 1
- Reversibility:
- not specified
- Remarks on result:
- other: erythema and eschar formation
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Remarks:
- intact skin
- Time point:
- 72 h
- Score:
- 0
- Reversibility:
- not specified
- Remarks on result:
- other: erythema and eschar formation
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Remarks:
- abraded skin
- Time point:
- 24 h
- Score:
- 1
- Reversibility:
- not specified
- Remarks on result:
- other: erythema and eschar formation
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Remarks:
- abraded skin
- Time point:
- 72 h
- Score:
- 2
- Reversibility:
- not specified
- Remarks on result:
- other: erythema and eschar formation
- Irritation parameter:
- erythema score
- Basis:
- animal #4
- Remarks:
- intact skin
- Time point:
- 24 h
- Score:
- 1
- Reversibility:
- not specified
- Remarks on result:
- other: erythema and eschar formation
- Irritation parameter:
- erythema score
- Basis:
- animal #4
- Remarks:
- intact skin
- Time point:
- 72 h
- Score:
- 0
- Reversibility:
- not specified
- Remarks on result:
- other: erythema and eschar formation
- Irritation parameter:
- erythema score
- Basis:
- animal #4
- Remarks:
- abraded skin
- Time point:
- 24 h
- Score:
- 2
- Reversibility:
- not specified
- Remarks on result:
- other: erythema and eschar formation
- Irritation parameter:
- erythema score
- Basis:
- animal #4
- Remarks:
- abraded skin
- Time point:
- 72 h
- Score:
- 1
- Reversibility:
- not specified
- Remarks on result:
- other: erythema and eschar formation
- Irritation parameter:
- erythema score
- Basis:
- animal #5
- Remarks:
- intact skin
- Time point:
- 24 h
- Score:
- 2
- Reversibility:
- not specified
- Remarks on result:
- other: erythema and eschar formation
- Irritation parameter:
- erythema score
- Basis:
- animal #5
- Remarks:
- intact skin
- Time point:
- 72 h
- Score:
- 1
- Reversibility:
- not specified
- Remarks on result:
- other: erythema and eschar formation
- Irritation parameter:
- erythema score
- Basis:
- animal #5
- Remarks:
- abraded skin
- Time point:
- 24 h
- Score:
- 2
- Reversibility:
- not specified
- Remarks on result:
- other: erythema and eschar formation
- Irritation parameter:
- erythema score
- Basis:
- animal #5
- Remarks:
- abraded skin
- Time point:
- 72 h
- Score:
- 2
- Reversibility:
- not specified
- Remarks on result:
- other: erythema and eschar formation
- Irritation parameter:
- erythema score
- Basis:
- animal #6
- Remarks:
- intact skin
- Time point:
- 24 h
- Score:
- 1
- Reversibility:
- not specified
- Remarks on result:
- other: erythema and eschar formation
- Irritation parameter:
- erythema score
- Basis:
- animal #6
- Remarks:
- intact skin
- Time point:
- 72 h
- Score:
- 1
- Reversibility:
- not specified
- Remarks on result:
- other: erythema and eschar formation
- Irritation parameter:
- erythema score
- Basis:
- animal #6
- Remarks:
- abraded skin
- Time point:
- 24 h
- Score:
- 1
- Reversibility:
- not specified
- Remarks on result:
- other: erythema and eschar formation
- Irritation parameter:
- erythema score
- Basis:
- animal #6
- Remarks:
- abraded skin
- Time point:
- 72 h
- Score:
- 1
- Reversibility:
- not specified
- Remarks on result:
- other: erythema and eschar formation
- Irritation parameter:
- erythema score
- Basis:
- animal: all animals
- Remarks:
- intactact and abraded skin average subtotal
- Time point:
- 24/48/72 h
- Score:
- 6.51
- Reversibility:
- not specified
- Remarks on result:
- other: erythema and eschar formation
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Remarks:
- intact skin
- Time point:
- 24 h
- Score:
- 2
- Reversibility:
- not specified
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Remarks:
- intact skin
- Time point:
- 72 h
- Score:
- 3
- Reversibility:
- not specified
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Remarks:
- abraded skin
- Time point:
- 24 h
- Score:
- 2
- Reversibility:
- not specified
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Remarks:
- abraded skin
- Time point:
- 72 h
- Score:
- 3
- Reversibility:
- not specified
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Remarks:
- intact skin
- Time point:
- 24 h
- Score:
- 1
- Reversibility:
- not specified
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Remarks:
- intact skin
- Time point:
- 72 h
- Score:
- 1
- Reversibility:
- not specified
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Remarks:
- abraded skin
- Time point:
- 24 h
- Score:
- 1
- Reversibility:
- not specified
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Remarks:
- abraded skin
- Time point:
- 72 h
- Score:
- 1
- Reversibility:
- not specified
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Remarks:
- intact skin
- Time point:
- 24 h
- Score:
- 1
- Reversibility:
- not specified
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Remarks:
- intact skin
- Time point:
- 72 h
- Score:
- 0
- Reversibility:
- not specified
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Remarks:
- abraded skin
- Time point:
- 24 h
- Score:
- 1
- Reversibility:
- not specified
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Remarks:
- abraded skin
- Time point:
- 72 h
- Score:
- 2
- Reversibility:
- not specified
- Irritation parameter:
- edema score
- Basis:
- animal #4
- Remarks:
- intact skin
- Time point:
- 24 h
- Score:
- 1
- Reversibility:
- not specified
- Irritation parameter:
- edema score
- Basis:
- animal #4
- Remarks:
- intact skin
- Time point:
- 72 h
- Score:
- 0
- Reversibility:
- not specified
- Irritation parameter:
- edema score
- Basis:
- animal #4
- Remarks:
- abraded skin
- Time point:
- 24 h
- Score:
- 2
- Reversibility:
- not specified
- Irritation parameter:
- edema score
- Basis:
- animal #4
- Remarks:
- abraded skin
- Time point:
- 72 h
- Score:
- 2
- Reversibility:
- not specified
- Irritation parameter:
- edema score
- Basis:
- animal #5
- Remarks:
- intact skin
- Time point:
- 24 h
- Score:
- 1
- Reversibility:
- not specified
- Irritation parameter:
- edema score
- Basis:
- animal #5
- Remarks:
- intact skin
- Time point:
- 72 h
- Score:
- 1
- Reversibility:
- not specified
- Irritation parameter:
- edema score
- Basis:
- animal #5
- Remarks:
- abraded skin
- Time point:
- 24 h
- Score:
- 1
- Reversibility:
- not specified
- Irritation parameter:
- edema score
- Basis:
- animal #5
- Remarks:
- abraded skin
- Time point:
- 72 h
- Score:
- 1
- Reversibility:
- not specified
- Irritation parameter:
- edema score
- Basis:
- animal #6
- Remarks:
- intact skin
- Time point:
- 24 h
- Score:
- 1
- Reversibility:
- not specified
- Irritation parameter:
- edema score
- Basis:
- animal #6
- Remarks:
- intact skin
- Time point:
- 72 h
- Score:
- 0
- Reversibility:
- not specified
- Irritation parameter:
- edema score
- Basis:
- animal #6
- Remarks:
- abraded skin
- Time point:
- 24 h
- Score:
- 1
- Reversibility:
- not specified
- Irritation parameter:
- edema score
- Basis:
- animal #6
- Remarks:
- abraded skin
- Time point:
- 72 h
- Score:
- 1
- Reversibility:
- not specified
- Irritation parameter:
- edema score
- Remarks:
- subtotal
- Basis:
- mean
- Time point:
- other: 24 h and 72 h
- Score:
- 5.16
- Reversibility:
- not specified
- Remarks on result:
- other: Study was done before OECD guidelines were established, hence there are no 48 h data available.
- Irritation parameter:
- other: erythema and eschar formation
- Remarks:
- subtotal
- Basis:
- mean
- Time point:
- other: 24 h and 72 h
- Score:
- 6.51
- Reversibility:
- not specified
- Remarks on result:
- other: Study was done before OECD guidelines were established, hence there are no 48 h data available.
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 48 h
- Reversibility:
- not specified
- Remarks on result:
- not measured/tested
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 48 h
- Reversibility:
- not specified
- Remarks on result:
- not measured/tested
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 48 h
- Reversibility:
- not specified
- Remarks on result:
- not measured/tested
- Irritation parameter:
- edema score
- Basis:
- animal #4
- Time point:
- 48 h
- Reversibility:
- not specified
- Remarks on result:
- not measured/tested
- Irritation parameter:
- edema score
- Basis:
- animal #5
- Time point:
- 48 h
- Reversibility:
- not specified
- Remarks on result:
- not measured/tested
- Irritation parameter:
- edema score
- Basis:
- animal #6
- Time point:
- 48 h
- Reversibility:
- not specified
- Remarks on result:
- not measured/tested
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 48 h
- Reversibility:
- not specified
- Remarks on result:
- not measured/tested
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 48 h
- Reversibility:
- not specified
- Remarks on result:
- not measured/tested
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 48 h
- Reversibility:
- not specified
- Remarks on result:
- not measured/tested
- Irritation parameter:
- erythema score
- Basis:
- animal #4
- Time point:
- 48 h
- Reversibility:
- not specified
- Remarks on result:
- not measured/tested
- Irritation parameter:
- erythema score
- Basis:
- animal #5
- Time point:
- 48 h
- Reversibility:
- not specified
- Remarks on result:
- not measured/tested
- Irritation parameter:
- erythema score
- Basis:
- animal #6
- Time point:
- 48 h
- Reversibility:
- not specified
- Remarks on result:
- not measured/tested
Any other information on results incl. tables
Barely perceptible to severe erythema and barely perceptible
to moderate edema were observed. A primary irritation index
of 2.92 was calculated.
Applicant's summary and conclusion
- Interpretation of results:
- irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The material is i r r i t a t i n g t o the skin of albino rabbits.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.