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Diss Factsheets
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EC number: 244-754-0 | CAS number: 22047-49-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
The assessment of biodegradation is based on 19 valid, reliable studies available within the category. In all of these studies the test substance was determined to be readily biodegradable. The study conducted with the read-across substance dodecanoic acid, isooctyl ester (CAS No. 84713-06-4) was not used for assessment, due to the low sludge concentration (1.6E03 cells/mL) in the test solution. Within this test, the substance almost fulfilled the criteria for ready biodegradation under the test conditions and would have probably passed if it had been tested with a higher, standard sludge concentration. Hence, the results of the biodegradation tests within the category are consistent, and the substances can be considered as readily biodegradable.
The 19 available studies cover the variability of the category with different alcohol and fatty acid chain lengths (MW 256.42 - 396.7 mg/L). The data gaps within the category can thus be filled by intrapolation. Only the smallest constituent of the UVCB isopentyl decanoate and octanoate (CAS No. 1365095-43-7) is outside the size range of the tested substances (MW 214.34 mg/L). However, the substance has practically the same structure as isopentyl laurate (CAS No. 6309-51-9), which was shown to be readily biodegradable, and having a shorter fatty acid chain, should be even more easily biodegraded (Bozcar et al., 2001).
In conclusion, the data available on biodegradation for the SCAE C2-C8 category show a clear, consistent pattern of ready biodegradability. SCAE C2-C8 is a robust category with a large amount of reliable, consistent data throughout the category. In each case of read-across, the best suited (highest degree of structural similarity, nearest physico-chemical properties) read-across substances were entered into IUCLID. Generally, larger and branched molecules are considered as a worst case approach, since the chain length and substitutions are determining factors for biodegradation of fatty acid alcohol esters (Boczar et al., 2001; Dias and Alexander, 1971). Furthermore, as can be seen in the data matrix of the category justification in Section 13, all reliable data in the category support the hazard assessment of each category member, by showing a consistent pattern of results.
Boczar, B.A., Forney, L., Begley, W., Larson, R.J. and Federle, T.W., 2001,Water Research Vol. 35, No. 17, pp. 4208–4216
Dias, F.F. and Alexander, M., 1971, Applied Microbiology, Vol. 22, No. 6, p. 1114-1118
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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