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EC number: 249-109-7 | CAS number: 28629-66-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
This substance is an EU Category 2 skin irritant and an EU Category 1 eye irritant with a specific concentration limit of 10% for eye irritation.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
Skin Irritation/Corrosion:
In a key study the test substance was applied undiluted or at concentrations of 50%, 25%, 12.5%, and 6.25% to groups of New Zealand white rabbits under semi-occlusive dressing for four hours (Kiplinger, G.R., 1993). Following the exposure period, the test sites were washed with light, white mineral oil and disposable paper towels. The test sites were evaluated in accordance with Draize. Mean 24-72 hour erythema and edema scores were 2.6 and 1.3, respectively, undiluted, 2.9 and 1.2, respectively at 50%, 2.7 and 0.7, respectively, at 12.5%, and 2.1 and 0.5, respectively, at 6.25%. All effects were not fully reversible at 72 hours.
In a supporting study the test substance was applied to New Zealand white rabbits under semi-occlusive dressing for four hours (Shults, S.K. et al., 1993). Following the exposure period, the test sites were wiped with gauze moistened with mineral oil and then gently patted with clean, dry paper towels. The test sites were evaluated in accordance with Draize. Mean 24-72 hour erythema and edema scores were 1.7 and 1.1, respectively. Erythema was not fully reversible in 14 days; edema was fully reversible in 4 days.
In another supporting study a 5% suspension of this substance was applied to New Zealand white rabbits under semi-occlusive dressing for four hours (Bonnette, K.L., 1996). Following the exposure period, the test sites were wiped with gauze moistened with mineral oil followed by dry gauze. The test sites were evaluated in accordance with EC guidelines (1993) which resulted in average scores at 24, 48, and 72 hours of 3.17, 2.17, and 1.83, respectively, for erythema and 1.67, 1.00, and 0.67, respectively, for edema. The mean values used for classification and labeling in accordance with GHS criteria were 1.11 for edema and 2.39 for erythema. Adverse effects were reversible in 14 days.
Serious eye damage/irritation:
In a keystudy the testmaterial was instilled in the eye of six albino rabbits (Hershman, RJ and Moore, GE, 1983).The group mean ocular irritation scores according to the Draize scale were 18.2, 20.7, 26.5, 28.8, 27.5, 7.0, and 5.6 out of 110 at 1, 2, 3, 4, 7, 14, and 21 days, respectively. Conjunctival and corneal effects were not fully reversible by day 21.
In a supporting study, a 15% suspension of this substance in mineral oil was administered to New Zealand white rabbits (Bonnette, K.L., 1996). Exposure to the test substance produces iritis in 3/6 test eyes at the 1 hour scoring interval. The iridal irritation resolved completely in the affected eyes by the 24 hours scoring interval. Conjunctivitis (redness, swelling and/or discharge) was noted in 6/6 test eyes at the 1 hour scoring interval. The conjunctival irritation resolved completely in all animals by 96 hours. The mean 24-72 hour scores for corneal opacity, iritis, conjunctivae redness and conjunctival edema were 0.00, 0.00, 1.00, and 0.61, respectively.
Effects on skin irritation/corrosion: moderately irritating
Effects on eye irritation: highly irritating
Justification for classification or non-classification
This substance meets the requirement under EU CLP (Regulation (EC) No. 1272/2008) for classification as a Category 2 skin irritant and a Category 1 eye irritant with a specific concentration limit of 15% for eye irritation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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