Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 248-471-3 | CAS number: 27458-94-2
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Scientifically valid, well documented and acceptable for assessment.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
- Principles of method if other than guideline:
- Method: BASF-Test
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Isononyl alcohol
- EC Number:
- 248-471-3
- EC Name:
- Isononyl alcohol
- Cas Number:
- 27458-94-2
- Molecular formula:
- C9H20O
- IUPAC Name:
- 3,5,5-trimethylhexan-1-ol
- Details on test material:
- A01-03: Isononanol IFP octene source
Isononylalcohol from IFP octene source, purity: 96.15%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- breeder: Wiga, Sulzfeld, Germany
Age: about 6 - 8 weeks at start of the study
Mean body weights prior to exposure: males: 257 g, females: 209 g
Feeding: commercial diet (Herilan, MRH maintenance diet, Rinteln, Germany) ad libitum
Drinking water ad libitum
Room temperature: 22 +/-2°C
Relative humidity: 55 +/- 5%
Lightening: 12 h dark, 12 h light
Administration / exposure
- Route of administration:
- inhalation: vapour
- Duration of exposure:
- 7 h
- No. of animals per sex per dose:
- 3
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC0
- Effect level:
- > 0.21 mg/L air (nominal)
- Exp. duration:
- 7 h
Any other information on results incl. tables
No animal died during exposure or the 14 day observation period. No clinical or gross pathological findings were noted.
The mean concentration calculated during the 7 h exposure was 0.21 mg/l.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
