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EC number: 700-064-6 | CAS number: 2105830-60-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: guideline study and GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 008
- Report date:
- 2008
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 B (Ready Biodegradability: CO2 Evolution Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Esterification product of castor oil and tetrahydromethyl-1,3-isobenzofuranedione
- EC Number:
- 700-064-6
- Cas Number:
- 2105830-60-0
- Molecular formula:
- Not applicable as this is a UVCB substance
- IUPAC Name:
- Esterification product of castor oil and tetrahydromethyl-1,3-isobenzofuranedione
1
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Duration of test (contact time):
- 29 d
Initial test substance concentration
- Initial conc.:
- 17 mg/L
- Based on:
- test mat.
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- CO2 evolution
Reference substance
- Reference substance:
- acetic acid, sodium salt
Results and discussion
% Degradation
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 2 - 14
- Sampling time:
- 29 d
- Details on results:
- Determination of ‘ready’ biodegradability: carbon dioxide (CO2) evolution test (modified Sturm test) with the Substance.
The study procedure was based on EEC directive 92/69, C.4-C, December 1992, OECD guideline No. 301 B July 17, 1992 and
ISO Standard 9439 (1999). The Substance was a very viscous amber liquid. The Substance was tested in duplicate at
approximately 34 mg per 2 litres, corresponding to 12 mg TOC/l. The organic carbon content was based on the composition
and structure. Preparation was as much as possible performed under yellow light and/or dimmed light conditions. The
Theoretical CO2 production (ThCO2) of the Substance was estimated to be 2.60 mg CO2/mg.
In a pre-test the Substance was not sufficiently soluble to allow preparation of an aqueous solution at a concentration
of 1 g/l. Therefore, the Substance was weighed on glass slides and quantitatively added to the test bottles (2 litres)
containing medium with microbial organisms and mineral components. The test solutions were continuously stirred during
the test, to ensure optimal contact between the test substance and the test organisms. The relative degradation values calculated
from the measurements performed during the test period revealed 14 and 2% degradation of the Substance, for the duplicate
bottles tested. Thus, the criterion for ready biodegradability (at least 60% biodegradation within a 10-day window) was not met.
In the toxicity control, the Substance was found not to inhibit microbial activity. Since all criteria for acceptability of the test
were met, this study was considered to be valid. In conclusion, the Substance is designated as not readily biodegradable.
Any other information on results incl. tables
Reference substance
Identification number RS186
Name Sodium acetate
Description White powder (determined at NOTOX)
Molecular formula CH3COONa (taken from label)
Molecular weight 82.03 (taken from label)
Batch number K34333668
Article number 1.06268.0250
Purity 99.0%
Expiry Date 28 February 2010
Certified Yes
Storage conditions At room temperature in the dark
Supplier Merck, Darmstadt, Germany
Reference substance concentration and preparation of test solutions
A solution of sodium acetate was prepared by dissolving 402.0 mg in Milli-RO water and making
this up to a total volume of 100 ml. Volumes of 20 ml from this stock solution were added to 2
litres of the test medium of the positive control bottle and the toxicity control bottle, resulting in a
final concentration of 40 mg sodium acetate per litre (12 mg TOC/l).
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- under test conditions no biodegradation observed
- Conclusions:
- The Substance was not readily biodegradable under the conditions of the modified Sturm
test presently performed. - Executive summary:
SUMMARY
Determination of ‘ready’ biodegradability: carbon dioxide (CO2) evolution test (modified Sturm
test) with the Substance.
The study procedure was based on EEC directive 92/69, C.4-C, December 1992, OECD
guideline No. 301 B July 17, 1992 and ISO Standard 9439 (1999).
The Substance was a very viscous amber liquid. The Substance was tested in duplicate
at approximately 34 mg per 2 litres, corresponding to 12 mg TOC/l. The organic carbon content
was based on the composition and structure. Preparation was as much as possible performed
under yellow light and/or dimmed light conditions. The Theoretical CO2 production (ThCO2) of
the Substance was estimated to be 2.60 mg CO2/mg.
In a pre-test the Substance was not sufficiently soluble to allow preparation of an aqueous
solution at a concentration of 1 g/l. Therefore, the Substance was weighed on glass slides
and quantitatively added to the test bottles (2 litres) containing medium with microbial organisms
and mineral components. The test solutions were continuously stirred during the test, to ensure
optimal contact between the test substance and the test organisms.
The relative degradation values calculated from the measurements performed during the test
period revealed 14 and 2% degradation of the Substance, for the duplicate bottles tested.
Thus, the criterion for ready biodegradability (at least 60% biodegradation within a 10-day
window) was not met.
In the toxicity control, the Substance was found not to inhibit microbial activity.
Since all criteria for acceptability of the test were met, this study was considered to be valid.
In conclusion, the Substance is designated as not readily biodegradable.
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