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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
in vitro gene mutation study in bacteria
Remarks:
Type of genotoxicity: gene mutation
Type of information:
other: taken from literature
Adequacy of study:
key study
Study period:
1982-1983
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
publication
Title:
MUTAGENICITY OF SOME ANILINE DERIVATIVES
Author:
SHIMIZU,H AND TAKEMURA,N;
Year:
1983
Bibliographic source:
OCCUP. HEALTH CHEM. IND., PROC. INT. CONGR., 11TH:497-506, 1983

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 471 (Bacterial Reverse Mutation Assay)
Deviations:
not specified
GLP compliance:
not specified
Type of assay:
bacterial reverse mutation assay

Test material

Constituent 1
Chemical structure
Reference substance name:
3-aminobenzenesulphonic acid
EC Number:
204-473-6
EC Name:
3-aminobenzenesulphonic acid
Cas Number:
121-47-1
Molecular formula:
C6H7NO3S
IUPAC Name:
3-aminobenzene-1-sulfonic acid
Test material form:
solid: particulate/powder
Remarks:
migrated information: powder

Method

Species / strain
Species / strain / cell type:
S. typhimurium TA 1535, TA 1537, TA 98, TA 100 and E. coli WP2
Metabolic activation:
with and without
Metabolic activation system:
rat S9 mix
Test concentrations with justification for top dose:
0, 312.5, 625, 1250, 2500, 5000 µg/plate (with and without S9 mix)
Vehicle / solvent:
DMSO
Controls
Untreated negative controls:
no
Negative solvent / vehicle controls:
yes
True negative controls:
no
Positive controls:
yes
Positive control substance:
other: 2-(2-Furyl)-3-(5-nitro-furyl)acrylamide, sodium azide, 9-aminiacridine, 2-aminoanthracene

Results and discussion

Test results
Species / strain:
S. typhimurium TA 1535, TA 1537, TA 98, TA 100 and E. coli WP2
Metabolic activation:
with and without
Genotoxicity:
negative
Cytotoxicity / choice of top concentrations:
not determined
Vehicle controls validity:
valid
Untreated negative controls validity:
not examined
Positive controls validity:
valid
Remarks on result:
other: all strains/cell types tested
Remarks:
Migrated from field 'Test system'.

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information):
negative with metabolic activation
negative without metabolic activation

Based on the published data, the test item has to be considered as not mutagenic in the Ames test described in the literature