Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-826-1 | CAS number: 111-02-4
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1971
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Secondary source
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 972
- Report date:
- 1972
- Reference Type:
- secondary source
- Title:
- Final Report on the Safety Assessment of Squalane and Squalene
- Author:
- CIR Expert panel
- Year:
- 1 982
- Bibliographic source:
- International Journal of Toxicology 1982 1: 37
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- not applicable
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene
- EC Number:
- 203-826-1
- EC Name:
- 2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene
- Cas Number:
- 111-02-4
- Molecular formula:
- C30H50
- IUPAC Name:
- 2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene
- Test material form:
- other: liquid
- Details on test material:
- No data
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Doses:
- 5.0, 12.5, 25.0, 50.0 ml/kg
- No. of animals per sex per dose:
- groups with 5, 5, 10 and 10 mice
- Control animals:
- not specified
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- ca. 50 mL/kg bw
- Based on:
- test mat.
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 50 mL/kg bw
- Based on:
- test mat.
- Mortality:
- no mortality observed
- Clinical signs:
- other: no clinical signs observed
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- In the seven-day observation period, no toxic effects were observed and no deaths occurred. The single dose oral LD50 was determined to be greater than 50 ml/kg in mice.
- Executive summary:
Squalene has been tested for acute oral toxicity on mice. The single dose oral LD50 was determined to be greater than 50 ml/kg.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
