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EC number: 202-710-8 | CAS number: 98-88-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: This study is considered not reliable as only one test animal was used for studying the organ distribution as well as the excretion. Thus there are significant methodological deficiences and the study is rated Klimisch 3b.
Data source
Reference
- Reference Type:
- publication
- Title:
- Adhesion of synthetic organic polymer to soft tissue IV. Evualtion of a silicone adhesive system
- Author:
- Wang P.Y. and Ewans D.W.
- Year:
- 1 977
- Bibliographic source:
- Biomat., Med. Dev., Art. Org.; 5(3): 277-291
Materials and methods
- Objective of study:
- distribution
- excretion
- Principles of method if other than guideline:
- Labelled benzoyl chloride was applied over a 3 cm² area on the dorsal musculature of two male Wistar rat through a small incision. Of one of these rats urine and feces was collected during a 15 day period. The major internal organs of the other rat were isolated after 3 days.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Benzoyl chloride
- EC Number:
- 202-710-8
- EC Name:
- Benzoyl chloride
- Cas Number:
- 98-88-4
- Molecular formula:
- C7H5ClO
- IUPAC Name:
- benzoyl chloride
- Details on test material:
- - Name of test material (as cited in study report): benzoyl chloride
- Specific activity (if radiolabelling): 3µc/µL
- Locations of the label (if radiolabelling): 14C-carboxyl labelled benzoyl chloride
- Other:
radio-active benzoyl was separated by distillation, further purified and sterilized after preparation
Constituent 1
- Radiolabelling:
- yes
- Remarks:
- 14C-carboxyl labelling
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
Administration / exposure
- Route of administration:
- subcutaneous
- Vehicle:
- unchanged (no vehicle)
- Duration and frequency of treatment / exposure:
- Organ distribution: One application, maesurement after 3 days
Excretion: One application and measurements over 15 day period
Doses / concentrations
- Remarks:
- Doses / Concentrations:
10 µL
- No. of animals per sex per dose / concentration:
- Organ distribution: 1
Excretion: 1 - Control animals:
- yes
Results and discussion
- Preliminary studies:
- No data
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- No data
- Details on distribution in tissues:
- Heart < brain < kidneys < spleen < liver < lungs < skin/muscle
- Details on excretion:
- Only a very small amount of radioactivity was found in the urine and feces measured over a period of 15 d.
Metabolite characterisation studies
- Metabolites identified:
- no
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): no data
The authors tested the distribution in organs and the excretion via urine and feces of benzoyl chloride. Labelled benzoyl chloride was applied over a 3 cm² area on the dorsal musculature of two male Wistar rats through a small incision. Of one of these rats urine and feces was collected during a 15 day period., while the major internal organs of the other rat were isolated after 3 days. In these test conditions only a very small amount of radioactivity was found in the urine and feces measured over a period of 15 d. The distribution of benzoyl chloride was as follows: heart < brain < kidneys < spleen < liver < lungs < skin/muscle. - Executive summary:
The authors tested the distribution in organs and the excretion via urine and feces of benzoyl chloride (CAS n° 98-88-4). Labelled benzoyl chloride (10µL, specific activity 3 µc/µL) was applied over a 3 cm² area on the dorsal musculature of two male Wistar rats through a small incision. Of one of these rats urine and feces was collected during a 15 day period., while the major internal organs of the other rat were isolated 3 days after application. In these test conditions only a very small amount of radioactivity was found in the urine and feces measured over a period of 15 d. Furthermore, the distribution of benzoyl chloride was as follows: heart < brain < kidneys < spleen < liver < lungs < skin/muscle.
No data is available on the GLP status of this study. Moreover, this study is considered not reliable as only one test animal was used for studying the organ distribution as well as the excretion via urine and feces. Hence there are significant methodological deficiences and the study is rated Klimisch 3b.
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