Registration Dossier
Registration Dossier
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EC number: 482-110-2 | CAS number: -
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Absorption and metabolism: The high water solubility (>1561 g/l) and the partition coefficient (log Pow -2.9) of the substance indicate that a passive absorption by diffusion through cell membranes including dermal absorption may be limited. According to the results from animal testing, the substance was relatively well absorbed from the gastrointestinal tract and from skin. It can be assumed that the corrosive properties of the substance would have enhanced its uptake. Nevertheless, the bioaccumulation potential is negligible and metabolic degradation such as e.g. enzymatic hydroxylation and transformation of the functional groups is conceivable.
Distribution and excretion: The substance and its metabolites are anticipated to be distributed from the hepatic portal vein into the liver and into the kidneys where the soluble metabolites, including conjugated metabolites, are excreted via urine.
No other indications on the toxicokinetic behaviour of the substance could be derived from the results of the available studies.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
