3,7-dimethyloct-6-en-1-yn-3-ol

Short-term toxicity to aquatic invertebrates

Administrative data

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

experimental study

Adequacy of study:

key study

Study period:

01/03/1988 - 03/03/1988

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Study according to international guideline (OECD Guideline 202)

Cross-reference

Cross-reference 1

Reason / purpose for cross-reference:

reference to same study

Cross-reference 2

Reason / purpose for cross-reference:

reference to other study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1988

Report date:

1988

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)

Deviations:

yes

Remarks:

in darkness

Principles of method if other than guideline:

not relevant

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

3,7-dimethyloct-6-en-1-yn-3-ol

EC Number:

249-482-6

EC Name:

3,7-dimethyloct-6-en-1-yn-3-ol

Cas Number:

29171-20-8

Molecular formula:

C10H16O

IUPAC Name:

3,7-dimethyloct-6-en-1-yn-3-ol

Details on test material:

- Name of test material (as cited in study report): Deyhdrolinalool
- Physical state: Liquid
- Storage condition of test material: At room temperature

Specific details on test material used for the study:

Details on properties of test surrogate or analogue material (migrated information):
Not relevant

Sampling and analysis

Analytical monitoring:

no

Details on sampling:

- Concentrations: Nominal: 3.1, 6.3, 12.5, 25, 50 and 100 mg/l

Test solutions

Vehicle:

yes

Details on test solutions:

- Controls: Yes, water (blank) and vehicle controls

Test organisms

Test organisms (species):

Daphnia magna

Details on test organisms:

TEST ORGANISM
- Common name: Daphnia magna
- Strain: Straus 1820
- Source: National de Recherche Chimique Appliquee, Frankreich

Study design

Test type:

static

Water media type:

freshwater

Limit test:

no

Total exposure duration:

48 h

Remarks on exposure duration:

in darkness

Post exposure observation period:

Not relevant

Test conditions

Hardness:

2.7 or 0.5 mmol CaCO3

Test temperature:

20°C

pH:

8.0, no increase >0.1 during the experiment.

Dissolved oxygen:

8.4-8.85 mg/L, no decrease >3% during the experiment.

Salinity:

Not relevant

Nominal and measured concentrations:

Nominal: 3.1, 6.3, 12.5, 25, 50 and 100 mg/l

Details on test conditions:

TEST SYSTEM
- Test vessel:
- Type (delete if not applicable): open
- Material, size, headspace, fill volume: beakers containing 100 ml test solution covered with watch glasses
- Aeration: None, but water was aerated with clean air for at least 24 hours before use.
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4
- No. of vessels per vehicle control (replicates): 4






OTHER TEST CONDITIONS
- Photoperiod: diffuse light

EFFECT PARAMETERS MEASURED (with observation intervals if applicable): immobilization


TEST CONCENTRATIONS
- Spacing factor for test concentrations: 1.8

Reference substance (positive control):

no

Results and discussion

Effect concentrations

Effect concentrations 1

Duration:

48 h

Dose descriptor:

EC50

Effect conc.:

45.1 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mobility

Remarks on result:

other: 95%CL: 40.3 - 49.9 mg/l

Effect concentrations 2

Duration:

24 h

Dose descriptor:

EC50

Effect conc.:

53.6 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mobility

Remarks on result:

other: 95%CL: 46 - 62.4 mg/l

Effect concentrations 3

Duration:

48 h

Dose descriptor:

NOEC

Effect conc.:

25 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mobility

Effect concentrations 4

Duration:

48 h

Dose descriptor:

EC100

Effect conc.:

100 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mobility

Details on results:

- Mortality of control: 0% in blanks, 0% in vehicle controls

toxicity values were calculated based on nominal concentrations.

Results with reference substance (positive control):

Not relevant

Any other information on results incl. tables

not relevant

Applicant's summary and conclusion

Validity criteria fulfilled:

yes

Remarks:

Not more than 10% immobilization in controls, oxygen content above 3 mg/l

Conclusions:

The 48h EC50 of Dehydrolinalool to Daphnia magna is 45.1 mg/l.

Executive summary:

The toxicity of Dehydrolinalool towards Daphnia magna was investigated according to OECD Guideline 202 under GLP. The 48h- EC50 was found to be 45.1 mg/l (40.3 - 49.9 mg/l), the 24h- EC50 was found to be 53.6 mg/l (46 - 62.4 mg/l). The 48h- NOEC was 25 mg/l.