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Diss Factsheets
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EC number: 201-209-1 | CAS number: 79-46-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1960
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: This study was conducted prior to GLP and Test Guidelines, but sufficient data is available for interpretation of results
Cross-reference
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 960
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Oral LD50 test: Groups of rats were exposed to a single oral dose of 2-nitropropane (P-1357) and observed for a 7-day period. Mortality was recorded and the lethal concentration required to produce 50% mortality estimated (LD50).
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2-nitropropane
- EC Number:
- 201-209-1
- EC Name:
- 2-nitropropane
- Cas Number:
- 79-46-9
- Molecular formula:
- C3H7NO2
- IUPAC Name:
- 2-nitropropane
- Details on test material:
- Purity of the material was not listed. The test material was assumed to be commercial grade. Therefore, it is assumed that it is of fairly high purity.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- Rats of unspecified strain and sex. Weight ranged from 150 to 180 grams.
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- water
- Details on oral exposure:
- 100 and 400 mg/ml stock solutions were prepared in water.
- Doses:
- 100, 200, 400, 800, and 1200 mg/kg bw
- No. of animals per sex per dose:
- 5 rats of unspecified sex per dose
- Control animals:
- no
- Details on study design:
- Oral LD50 test: 5 rats/dose were orally administered 100, 200, 400, 800, and 1200 mg/kg of 2-nitropropane. The animals were observed for 7 days after dosing.
Based on the morality at different levels, the oral LD0, LD50 and confidence limit, and LD100 were estimated. - Statistics:
- None
Results and discussion
- Preliminary study:
- No data
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 565 - 885 mg/kg bw
- Mortality:
- 100 mg/kg group = 0/5, 200 mg/kg group = 0/5, 400 mg/kg group = 0/5, 800 mg/kg group = 3/5, and 1200 mg/kg group = 5/5
- Clinical signs:
- other: In-life observations were progressive unsteadiness, weakness, incoordination ending in ataxia. Narcotic action was noted.
- Gross pathology:
- Two hours after ingestion: 1 rat dosed at 800 mg/kg level, unable to move around in cage, breathing is irregular. Eighteen hours after ingestion: 1 dead. Post-mortem results: lungs = Hemorrhaged; liver = dark areas; spleen = has a large dark spot; kidneys = spotted; stomach = gassous and contains gray fluid; and intestines = have bloody fluid.
Two more deaths occurred after 48 hours. Post-mortem results, generally same as above. - Other findings:
- None
Any other information on results incl. tables
mg/kg | No. of Rats | 1 | 2 | 3 | 4 | 5 | 6 | 7 |
100 | 5 | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 |
200 | 5 | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 |
400 | 5 | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 |
800 | 5 | 1/5 | 3/5 | 3/5 | 3/5 | 3/5 | 3/5 | 3/5 |
1200 | 5 | 5/5 |
Applicant's summary and conclusion
- Interpretation of results:
- other: Category 4
- Remarks:
- Criteria used for interpretation of results: other: EU GHS
- Conclusions:
- The oral LD50 in rats is 725 +/- 160 mg/kg/day
- Executive summary:
Oral LD50 test: 5 rats/dose were orally administered 100, 200, 400, 800, and 1200 mg/kg of 2-nitropropane wtih water as the vehicle. The animals were observed for 7 days after dosing. Post-mortem examinations were performed.
Based on the morality at different levels, the oral LD0, LD50 and confidence limit, and LD100 were estimated. The LD0 was 400 mg/kg; the LD50 was approximately 725 +/- 160 mg/kg, and the LD100 was 1200 mg/kg
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