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EC number: 242-016-2 | CAS number: 18127-01-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 3rd July 1980 to 1st August 1980
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The test substance was applied once to the clipped skin of New Zealand white rabbits at 5 g/kg over approximately 10 % of the body surface. Abrasions were made in half of the rabbits and extended the length of the exposure site, scratching only the strarum corneum, but did not reach the derma or produce bleeding. The area was covered with an occlusive dressing for 24 h after which the wrapping was removed and the exposed area was wiped, but not washed, to remove excess material. Dermal reactions were scored at 1, 7 and 14 days according to Draize. The rabbtis were observed daily for 14 days for signs of toxicity, pharmacological effects and mortality. All animals were examined for gross pathology at termiantion.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Bourgeonal
- IUPAC Name:
- Bourgeonal
- Reference substance name:
- 3-(4-tert-butylphenyl)propionaldehyde
- EC Number:
- 242-016-2
- EC Name:
- 3-(4-tert-butylphenyl)propionaldehyde
- Cas Number:
- 18127-01-0
- Molecular formula:
- C13H18O
- IUPAC Name:
- 3-(4-tert-butylphenyl)propanal
- Test material form:
- other: liquid
- Details on test material:
- - Name of test material (as cited in study report): Bourgeonal
- Physical state: Clear liquid
- Other: Specific gravity = 0.94
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Perfection Breeders, Nicholas Helf
- Age at study initiation: approximately 8 weeks old
- Weight at study initiation: 2.3 - 2.6 kg
- Housing: 2/ cage in suspended wire mesh cages
- Diet (e.g. ad libitum): Purina rabbit chow ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: At least 1 week
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: Back
- % coverage: 10 %
- Type of wrap if used: Gaize patches secured with adhesive tape and the trunks were wrapped with impervious material.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): Washing was not done but the test area was wiped to remove excess test material.
- Time after start of exposure: 24 h
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 5 g/kg. The dose was based on the sample weight as calculated from the specific gravity.
- Constant volume or concentration used: No, volume ranged from 12.2 to 13.8 cc.
- For solids, paste formed: Not applicable, test material is a liquid - Duration of exposure:
- Single exposure; the test material was not removed.
- Doses:
- 5 g/kg
- No. of animals per sex per dose:
- 6 females
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Dermal reactions were scored at 1, 7 and 14 days. The rabbits were scored daily for 14 days for signs of toxicity, pharmacological effects and mortality. Bodyweights were recorded pre-test and in the survivors at 14 days.
- Necropsy of survivors performed: Yes, all animals were examined for gross pathology.
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 5 other: g/kg
- Based on:
- test mat.
- Mortality:
- There was one death at Day 4.
- Clinical signs:
- other: In the rabbit that died, pre-death toxic signs were diarrhoea, tachypnea, prostration, flaccid muscle tone and spasm. Toxic sings in survivors included lethargy and diarrhoea. Slight to moderate erythema was noted on Days 1 and 7 and was absent or slight
- Gross pathology:
- Necropsy findings of survivors were normal. The spontaneous death had lung abnormalities.
Applicant's summary and conclusion
- Conclusions:
- The test substance was assessed for acute dermal toxicity in New Zealand white rabbits. There were no treatment-related deaths therefore the LD50 was > 5.0 g/kg.
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