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EC number: 279-815-0 | CAS number: 81782-77-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Not reported
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study was performed to sound scientific principles with a sufficient level of detail to assess the quality of the submitted data.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- study with volunteers
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Repeated insult patch tests were conducted on 50 human subjects. The volunteers were exposed to 10 dermal applications of 8 different substance during induction exposure and 10 - 24 days after application of the last induction exposure, challenge patches were applied to the original contact sites and also to fresh, adjacent sites. The sites were scored prior to the next patch application during the induction exposure period and at 24 and 48 hours following the challenge application.
- GLP compliance:
- no
- Remarks:
- not applicable
Test material
- Reference substance name:
- 4-methyl-3-decen-5-ol
- EC Number:
- 279-815-0
- EC Name:
- 4-methyl-3-decen-5-ol
- Cas Number:
- 81782-77-6
- Molecular formula:
- C11H22O
- IUPAC Name:
- 4-methyldec-3-en-5-ol
- Test material form:
- liquid
Constituent 1
Method
- Type of population:
- not specified
- Ethical approval:
- confirmed and informed consent free of coercion received
- Subjects:
- - Number of subjects exposed: 60 volunteers (50 volunteers completed the study)- Sex: Male (14) and female (36)- Age: 16 to 65 years
- Clinical history:
- - History of allergy or casuistics for study subject or populations: All of the subjects did not exhibit any physical or dermatological conditions which would have precluded application of the test materials.
- Route of administration:
- dermal
- Details on study design:
- TYPE OF TEST(S) USED: patch test (epicutaneous test).ADMINISTRATION- Type of application: occlusive.- Vehicle / solvent: dimethyl phthalate.- Concentrations: 10 % solution of test material in dimethyl phthalate.- Volume applied: 0.2 mL- Testing/scoring schedule: Individuals were scored at 48 hours.MAIN STUDYA. INDUCTION EXPOSURE- Area of Site: 2 cm² on the inner side of the arm or the back of each subject.- Frequency of applications: 10.- Duration of exposure: 24 hours.- Rest period: The subjects removed the patched 24 hours after application. Twenty four hour rest periods followed removals on Tuesdays and Thursdays and 48 hour rest periods followed Saturday removals. This procedure was repeated until 10 applications were performed.- Test groups: 0.2 mL of test material.- Scoring: Sites were scored before each repeat application.- Concentrations: 10 % solution of test material in dimethyl phthalate.B. CHALLENGE EXPOSURE- Time after induction: 10 to 24 days after the last induction application.- Site: Induction site as well as fresh, adjacent site.- No. of exposures: 1.- Concentrations: 10 % test material solution in dimethyl phthalate.- Evaluation (hr after challenge): 24 and 48 hours.EXAMINATIONS- Grading/Scoring system: Volunteers were scored according to the following scale:No reaction = 0Minimal erythema = ±Erythema = 1Erythema and edema = 2Erythema and moderate edema with papules = 3Erythema, marked edema, substantial vesiculation = 4
Results and discussion
- Results of examinations:
- SYMPTOMS- Slight transient reactions were observed during testing.NO. OF PERSONS WITH/OUT REACTIONS COMPARED TO STUDY POPULATION- Number of subjects with positive reactions: 0- Number of subjects with negative reactions: 40 (10 subjects dropped out during the course of the test due to personal reasons)- Number of subjects with equivocal reactions: 0- Number of subjects with irritating reactions: 0
Any other information on results incl. tables
Table 1: Results (individual scores)
Panellist No. |
Age |
Sex |
Exposure no. |
Challenge |
||||||||||||
Original |
Virgin |
|||||||||||||||
1 |
2 |
3 |
4 |
5 |
6 |
7 |
8 |
9 |
10 |
24 h |
48 h |
24 h |
48 h |
|||
1 |
25 |
F |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
2 |
17 |
M |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
3 |
27 |
F |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
4 |
49 |
F |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
5 |
28 |
F |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
6 |
21 |
M |
Discontinued |
|||||||||||||
7 |
25 |
M |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
8 |
45 |
F |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
9 |
47 |
F |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
10 |
32 |
M |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
-* |
-* |
-* |
-* |
11 |
26 |
M |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
12 |
31 |
F |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
13 |
23 |
F |
Discontinued |
|||||||||||||
14 |
40 |
M |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
15 |
35 |
F |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
16 |
27 |
F |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
17 |
32 |
M |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
1 |
0 |
0 |
0 |
0 |
18 |
32 |
F |
Discontinued |
|||||||||||||
19 |
31 |
F |
Discontinued |
|||||||||||||
20 |
39 |
F |
Discontinued |
|||||||||||||
21 |
22 |
F |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
22 |
38 |
F |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
23 |
26 |
F |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
24 |
29 |
F |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
25 |
17 |
M |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
26 |
18 |
F |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
27 |
20 |
F |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
28 |
34 |
F |
0 |
0 |
Discontinued |
|||||||||||
29 |
27 |
F |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
30 |
20 |
F |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
31 |
38 |
F |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
32 |
34 |
F |
0 |
0 |
0 |
0 |
0 |
1 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
33 |
50 |
F |
0 |
Discontinued |
||||||||||||
34 |
42 |
F |
0 |
Discontinued |
||||||||||||
35 |
19 |
F |
Discontinued |
|||||||||||||
36 |
21 |
M |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
37 |
24 |
F |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
38 |
39 |
F |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
39 |
27 |
M |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
40 |
60 |
F |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
41 |
22 |
M |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
42 |
18 |
M |
0 |
Discontinued |
||||||||||||
43 |
20 |
F |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
± |
0 |
0 |
0 |
0 |
44 |
46 |
F |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
45 |
34 |
F |
0 |
Discontinued |
||||||||||||
46 |
35 |
F |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
47 |
31 |
F |
Discontinued |
|||||||||||||
48 |
65 |
M |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
49 |
66 |
F |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
50 |
35 |
F |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
51 |
30 |
F |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
52 |
34 |
F |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
*- |
- |
0 |
0 |
0 |
0 |
53 |
35 |
M |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
54 |
33 |
F |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
55 |
55 |
F |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
56 |
29 |
F |
0 |
0 |
Discontinued |
|||||||||||
57 |
25 |
M |
0 |
0 |
0 |
0 |
0 |
± |
0 |
0 |
0 |
± |
0 |
0 |
0 |
0 |
58 |
23 |
F |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
± |
± |
0 |
± |
0 |
59 |
26 |
F |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
60 |
18 |
F |
Discontinued |
|||||||||||||
61 |
19 |
F |
0 |
0 |
0 |
0 |
0 |
0 |
± |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
62 |
49 |
F |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
63 |
17 |
M |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
64 |
33 |
F |
Discontinued |
|||||||||||||
65 |
62 |
F |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
- no patch application h hours after application -* no reading taken |
Applicant's summary and conclusion
- Conclusions:
- The test material was determined to be not sensitising to human volunteers during a repeat insult patch test at a concentration of 10 %.
- Executive summary:
A human repeat insult patch test performed in 50 volunteers at a concentration of 10 % was performed to determine the skin sensitisation potential of the test material. Under the conditions of the test no sensitisation was observed, with only transient reactions noted in a few volunteers during the study.
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