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Diss Factsheets
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EC number: 219-348-1 | CAS number: 2421-28-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Precedes establishment of guidelines and GLP. Documentation is limited.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 963
- Report date:
- 1963
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 433 draft (Acute Inhalation Toxicity: Fixed Concentration Procedure) (not officially approved)
- GLP compliance:
- not specified
- Test type:
- fixed concentration procedure
- Limit test:
- yes
Test material
- Reference substance name:
- Benzophenone-3,3':4,4'-tetracarboxylic dianhydride
- EC Number:
- 219-348-1
- EC Name:
- Benzophenone-3,3':4,4'-tetracarboxylic dianhydride
- Cas Number:
- 2421-28-5
- Molecular formula:
- C17H6O7
- IUPAC Name:
- 5-(1,3-dioxo-1,3-dihydro-2-benzofuran-5-carbonyl)-1,3-dihydro-2-benzofuran-1,3-dione
- Reference substance name:
- 291-348-1
- IUPAC Name:
- 291-348-1
- Test material form:
- solid: crystalline
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
Administration / exposure
- Route of administration:
- inhalation: dust
- Type of inhalation exposure:
- whole body
- Vehicle:
- clean air
- Details on inhalation exposure:
- stainless steel inhalation chamber, 1530 L. Total air flow through the system was 50 liters per minute. The actual chamber concentration was not determined during the exposure. The mean theoretical concentration was calulated from the air flow and net loss of material was 4.72 mg per liter.
- Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 6 h
- Control animals:
- no
- Details on study design:
- During the exposure, all animals were continuously observed for mortality and toxic effects. Following exposures, the animals were group-housed in metal cages suspended above droppings. Food and water were freely available during the pre-exposure period of adjustment to the laboratory environment and the post-exposure period. During the 14 day post-exposure period, the animals were observed daily for possible latent effects. Necropsies were performed following the sacrifice of the test animals at the termination of the study.
- Statistics:
- no data
Results and discussion
Effect levels
- Key result
- Sex:
- male
- Dose descriptor:
- LC0
- Effect level:
- 4.44 mg/L air (nominal)
- Based on:
- test mat.
- Exp. duration:
- 6 h
- Remarks on result:
- other: No deaths
- Mortality:
- no deaths
- Clinical signs:
- other: Slight evidence of lung damage such as foci of consolidation were noted at time of necropsy. As these were also noted in control animals, they were not considered to be related to the test material.
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Remarks:
- Migrated information
- Conclusions:
- 1,3-Isobenzofurandione, 5,5'-carbonylbis- (BTDA) was tested for acute inhalation lethality in rats in a protocol similar to OECD 433. No deaths or adverse effects occurred at concentrations of 4.44 mg/L.
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