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Diss Factsheets
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EC number: 203-685-6 | CAS number: 109-59-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
The mutagenicity of 2-isopropoxyethanol was examined in a guideline Ames study using Salmonella typhimurium strains, TA98, TA100, TA1535 and TA1537, and in an Escherichia coli strain, WP2uvrA, at concentrations up to 5,000 μg/plate with or without an exogenous metabolic activation system. The substance did not show any mutagenic activity in any bacterial strain with or without metabolic activation.
In a guideline cytogenicity study Chinese Hamster Lung/IU cells were continuously treated with 2-isopropoxyethanol for 24 hours at concentrations of 263, 525 and 1050 μg/ml without metabolic activation. In another assay, the CHL/IU cells were briefly (6 hours) treated with 2 -isopropoxyethanol in the presence or absence of metabolic activation system at concentrations of 263, 525 and 1050 μg/ml. No increase in clastogenicity (structural chromosome aberration) or polyploidy was observed in either study.
There are no studies available on the mammalian cell gene mutation potential of isopropoxyethanol. Studies are available on two structurally similar substances: In an in vitro mammalian cell gene mutation assay, chinese hamster ovary cells (CHO-K1-BH4-D1) were exposed to 2 -butoxyethanol, a close analogue of isopropoxyethanol, up to concentrations of 1% (v/v), with or without an S-9 metabolic activating system from Arochlor 1254 induced rat liver. Doses were selected based on low cytotoxicity to CHO cells in a preliminary study. No treatment-related effects were seen, either in the presence or absence of a metabolic activating system. This result can be considered representative of the mutagenic properties of isopropoxyethanol. In a reliable guideline mammalian cell gene mutation study using mouse lymphoma 5178Y cells, ethylene glycol n-propoxy ether was negative when tested up to the limit dose concentration when tested with and without metabolic activation. In a gene mutation study, null responses were obtained at the gpt locus in CHO-AS52 cells exposed to either 2 -butoxyethanol at concentrations up to 0.9 mg/ml or its metabolite butoxyacetaldehyde at concentrations up to 0.065 % (v/v), the highest doses which did not cause cytotoxicity at a sufficient level to prohibit its evaluation for mutagenicity.
Short description of key information:
Bacterial mutation: negative
Cytotoxicity: negative
Mammalian cell gene mutation: negative, based on structural analogues.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
The substance has no mutagenic properties and classification is therefore not warranted.
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