Registration Dossier
Registration Dossier
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EC number: 206-532-1 | CAS number: 353-42-4
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: well-documented, non-guideline and non-GLP study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 965
- Report date:
- 1965
Materials and methods
- Principles of method if other than guideline:
- according to BASF-internal standard
- GLP compliance:
- no
Test material
- Reference substance name:
- Dimethyl ether-boron trifluoride
- EC Number:
- 206-532-1
- EC Name:
- Dimethyl ether-boron trifluoride
- Cas Number:
- 353-42-4
- Molecular formula:
- C2H6BF3O
- IUPAC Name:
- (dimethyloxo)trifluoro-λ⁵-borane
- Test material form:
- other: liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated skin of the same animal
- Amount / concentration applied:
- ca. 0.1 ml
- Duration of treatment / exposure:
- 1 min, 5 min, 15 min, 20 h
- Observation period:
- 8 days
- Number of animals:
- 2
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- other: redness
- Basis:
- mean
- Time point:
- other: 1 min
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 8 days
- Remarks on result:
- other: reading 24 h
- Irritation parameter:
- other: scaliness
- Basis:
- mean
- Time point:
- other: 5 min
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 8 days
- Irritation parameter:
- other: necrosis
- Basis:
- mean
- Time point:
- other: 15 min
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 8 days
- Irritation parameter:
- other: necrosis
- Basis:
- mean
- Time point:
- other: 20 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 8 days
- Remarks on result:
- other: necrotic muscle on the dorsum and loss of 2/3 of the ear
Applicant's summary and conclusion
- Interpretation of results:
- highly corrosive
- Remarks:
- Migrated information
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