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EC number: 200-935-6 | CAS number: 76-12-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- repeated dose toxicity: inhalation
- Remarks:
- other: not specified
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The source is considered reliable since reported information is based on a review of existing peer-reviewed scientific literature by committees of experts in public health and related sciences.
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- 1,1,2,2-TETRACHLORO-1,2-DIFLUOROETHANE
- Author:
- American Conference of Industrial Hygienists (ACGIH)
- Year:
- 2 008
- Bibliographic source:
- 1,1,2,2-Tetrachloro-1,2-Difluoroethane: TLV® Chemical Substances 7th Edition Documentation ACGIH® Publication
- Reference Type:
- review article or handbook
- Title:
- Dangerous Properties of Industrial Materials
- Author:
- Sax NI
- Year:
- 1 975
- Bibliographic source:
- Dangerous Properties of Industrial Materials, 4th ed., p1146.
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 947
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 963
- Reference Type:
- publication
- Title:
- Fluorocarbon toxicity and biological action.
- Author:
- Clayton J W
- Year:
- 1 967
- Bibliographic source:
- Fluorine Chem Rev1:197-252
- Reference Type:
- publication
- Title:
- The subacute inhaltion toxicity of 109 industrial chemicals.
- Author:
- Gage JC
- Year:
- 1 970
- Bibliographic source:
- Br JInd Med 27:1-18 (1970)
Materials and methods
- Principles of method if other than guideline:
- discussion on literature data of subchronic and subacute toxicty by inhalation.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 1,1,2,2 -tetrachloro-1,2 –difluoroethane
- IUPAC Name:
- 1,1,2,2 -tetrachloro-1,2 –difluoroethane
- Reference substance name:
- Tetrachloro-1,2-difluoroethane
- EC Number:
- 200-935-6
- EC Name:
- Tetrachloro-1,2-difluoroethane
- Cas Number:
- 76-12-0
- Molecular formula:
- C2Cl4F2
- IUPAC Name:
- 1,1,2,2-tetrachloro-1,2-difluoroethane
- Details on test material:
- Name of test material (as cited in study report):
1,1,2,2-tetrachloro-1,2-difluoroethane, CFC-112; 1,2-DIfluoro-1,1,2,2-tetrachloroethane; Halocarbon 112; Refrigerant 112
Constituent 1
Constituent 2
Test animals
- Species:
- other: Rat, Mouse, Guinea pig, Rabbit
Results and discussion
Effect levels
- Dose descriptor:
- LOEC
- Effect level:
- 500 ppm
- Based on:
- test mat.
- Sex:
- not specified
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
The following studies and results are reported under ACGIH sheet:
Tested animals |
Concentration |
Exposure |
Significant results and main clinical signs |
Reference |
10 rats |
500 ppm |
7 hours/day |
Irritation of the bronchiolar passages at 1000 ppm. |
Sax, 1975 |
16 guinea pigs |
500 ppm |
7 hours/day |
Fatty degeneration, necrosis and regenerative changes of the liver. |
Sax, 1975 |
4 rabbits |
500 ppm |
7 hours/day |
No information on results reported. |
Sax, 1975 |
10 rats |
|
6 hours/day |
The only significan sign of toxicity was a reduction in weight gain. |
DuPont Company, 1947, 1963 |
16 rats |
1000 ppm |
6 hours/day |
No clinical signs of systemic toxicity.Body weights of animals were within normal limits.Gross pathology and histopathology relealed very minor changes in the liver and slight aggravation of the usual type of pneumonitis seen in the rat strain employed |
Clayton et al, 1967 |
10 mice |
1000 ppm |
6 hours/day |
No clinical signs of systemic toxicity.Body weights of animals were within normal limits. |
Clayton et al, 1967 |
2 guinea pigs |
1000 ppm |
6 hours/day |
No clinical signs of systemic toxicity.Body weights of animals were within normal limits. |
Clayton et al, 1967 |
1 rabbit |
1000 ppm |
6 hours/day |
No clinical signs of systemic toxicity.Body weights of animals were within normal limits. |
Clayton et al, 1967 |
5 rats |
1000 ppm |
18 hours/day |
No effect. |
Gage, 1970 |
rats |
3000 ppm |
4 hours/day |
CNS and respiratory signs. No deaths. |
Gage, 1970 |
4 rats |
5000 ppm |
4 hours/day |
Signs of discomfort, muscular incoordination, slight narcosis during exposure with rapid recovery. |
Gage, 1970 |
4 rats |
2500 ppm |
4 hours/day |
Same signs of discomfort, muscular incoordination, and slight narcosis during exposure. Milder than the observed ones at exposure of 5000 ppm. Rapid recovery. |
Gage, 1970 |
Applicant's summary and conclusion
- Executive summary:
The American Conference of Governmental Industrial Hygienists(ACGIH) is a professional association of industrial hygienists and practitioners of related professions. One of the goals of the association is to provide information and guideline on exposure limits of substances in order to advance worker protection. ACGIHsheets are based on a review of existing peer-reviewed scientific literature by committees of experts in public health and related sciences and therefore ACGIH is considered a reliable secondary source of information.
The results of several repeted dose toxicity studies are reported.
1,1,2,2-tetrachloro-1,2-difluoroethanedoes not meet the classification criteria for hazard classes related to repeated dose exposure by inhalation according to Regulation (EC) No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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