Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 207-306-5 | CAS number: 460-19-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Ethanedinitrile
Dermal exposure of rabbits to ethanedinitrile gas in an acute toxicity study indicates that ethanedinitrile is not a skin irritant no skin sensitisation was reported. Dermal exposure of rabbits to 10,000 ppm (~21 g/m3) of ethanedinitrile for eight hours, did not result in any clinical observations or macroscopic effects (McNerney and Schrenk 1960).
Skin sensitation or any other effect to skin was not observed in six-month exposure of monkeys and rats to sublethal doses (11 and 25 ppm) of ethanedinitrile (Lewis et al. 1984).
Cyanides
Relevant literature does not include any information relating to sensitising effects, neither dermal nor respiratory, of hydrogen cyanide and cyanides (WHO 2004). Hydrogen cyanide does not present any structural alert for skin sensitization; standard skin sensitization test is not feasible and sensitizing properties of cyanides or nitriles have not been suggested by the experience in humans over a period of many years of production and use.
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation: in vitro
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- an in vitro skin sensitisation study does not need to be conducted because the available in vitro test methods are not applicable for the substance and therefore an in vivo skin sensitisation study was conducted
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Available studies provide sufficient evidence that ethanedinitrile does not have skin sensitisation properties. Therefore LLNA study was not conducted
- GLP compliance:
- no
- Type of study:
- not specified
- Justification for non-LLNA method:
- Available studies provide sufficient evidence that ethanedinitrile does not have skin sensitisation properties. Therefore LLNA study was not conducted
- Specific details on test material used for the study:
- ethanedinitrile 99.5 %
- Species:
- rabbit
- Strain:
- not specified
- Remarks:
- albino rabbits
- Sex:
- male
- Vehicle:
- unchanged (no vehicle)
- Concentration:
- 10000 ppm
- No. of animals per dose:
- 4
- Parameter:
- SI
- Value:
- 10 000
- Test group / Remarks:
- 4
- Parameter:
- SI
- Remarks:
- Dermal exposure of rabbits to 10,000 ppm (~21 g/m3) of ethanedinitrile for eight hours, did not result in any clinical observations or macroscopic effects.
- Value:
- 10 000
- Test group / Remarks:
- 4
- Interpretation of results:
- other: CLP criteria not met
- Conclusions:
- Dermal exposure of rabbits to ethanedinitrile gas in an acute toxicity study indicates that ethanedinitrile is not a skin sensitiser. Dermal exposure of rabbits to 10,000 ppm (~21 g/m3) of ethanedinitrile for eight hours, did not result in any clinical observations or macroscopic effects.
- Executive summary:
Dermal exposure of rabbits to ethanedinitrile gas in an acute toxicity study indicates that ethanedinitrile is not a skin sensitiser. Dermal exposure of rabbits to 10,000 ppm (~21 g/m3) of ethanedinitrile for eight hours, did not result in any clinical observations or macroscopic effects.
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Whole body exposure
- GLP compliance:
- no
- Type of study:
- not specified
- Justification for non-LLNA method:
- Available studies provide sufficient evidence that ethanedinitrile does not have skin sensitisation properties. Therefore LLNA study was not conducted
- Specific details on test material used for the study:
- ethanedinitrile 99%
- Species:
- other: albino rat and Rhesus monkey
- Strain:
- other: Charles River Sprague-Dawley COBS and Maccaca mulatta
- Sex:
- male
- Route:
- epicutaneous, open
- Vehicle:
- unchanged (no vehicle)
- Concentration / amount:
- 0 ppm; 11 ppm; 25 ppm
- Day(s)/duration:
- 180
- No. of animals per dose:
- 5 monkeys per treatment group
30 rats per treatment group - Positive control substance(s):
- no
- Key result
- Reading:
- 1st reading
- Hours after challenge:
- 4 320
- Group:
- negative control
- Dose level:
- 11 ppm
- No. with + reactions:
- 0
- Total no. in group:
- 5
- Clinical observations:
- Dermal exposure to ethanedinitrile gas indicates that ethanedinitrile is not a skin sensitiser. Skin sensitation or any other effect to skin was not observed in six-month exposure of monkeys and rats to sublethal doses (11 and 25 ppm) of ethanedinitrile.
- Remarks on result:
- no indication of skin sensitisation
- Key result
- Reading:
- 1st reading
- Hours after challenge:
- 4 320
- Group:
- test chemical
- Dose level:
- 11 ppm
- No. with + reactions:
- 0
- Total no. in group:
- 5
- Clinical observations:
- Dermal exposure to ethanedinitrile gas indicates that ethanedinitrile is not a skin sensitiser. Skin sensitation or any other effect to skin was not observed in six-month exposure of monkeys and rats to sublethal doses (11 and 25 ppm) of ethanedinitrile.
- Remarks on result:
- no indication of skin sensitisation
- Key result
- Reading:
- 1st reading
- Hours after challenge:
- 4 320
- Group:
- positive control
- Dose level:
- 11 ppm
- No. with + reactions:
- 0
- Total no. in group:
- 5
- Clinical observations:
- Dermal exposure to ethanedinitrile gas indicates that ethanedinitrile is not a skin sensitiser. Skin sensitation or any other effect to skin was not observed in six-month exposure of monkeys and rats to sublethal doses (11 and 25 ppm) of ethanedinitrile.
- Remarks on result:
- no indication of skin sensitisation
- Interpretation of results:
- other: CLP criteria not met
- Conclusions:
- Dermal exposure to ethanedinitrile gas indicates that ethanedinitrile is not a skin sensitiser. Skin sensitation or any other effect to skin was not observed in six-month exposure of monkeys and rats to sublethal doses (11 and 25 ppm) of ethanedinitrile.
- Executive summary:
Dermal exposure to ethanedinitrile gas indicates that ethanedinitrile is not a skin sensitiser. Skin sensitation or any other effect to skin was not observed in six-month exposure of monkeys and rats to sublethal doses (11 and 25 ppm) of ethanedinitrile.
Referenceopen allclose all
Available studies provide sufficient evidence that ethanedinitrile does not have skin sensitisation properties.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
Justification for classification or non-classification
CLP criteria not met
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.